| Long name: |
PSAP Primary Polyclonal Antibody |
| Also known as: |
PSAP PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PSAP/PAP |
| Specificity: |
This is a highly specific antibody against PSAP/PAP |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
144-194/524 |
| Subcellular location: |
Secreted |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PSAP |
| Gene ID number: |
5660 |
| Swiss Prot: |
P07602 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
GM1 gangliosides by beta-galactosidase (EC 3, GPR37 and GPR37L1, Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases, Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3, Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3, Saposins are specific low-molecular mass non-enzymic proteins, rather than by solubilizing the substrate, these effects are mediated by its G-protein-coupled receptors, they participate in the lysosomal degradation of sphingolipids, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling, which takes place by the sequential action of specific hydrolases, 1, 1, 1, 1, 1, 1, 12), 2, 2, 2, 2, 22), 23) and globotriaosylceramide by alpha-galactosidase A (EC 3, 4, 45) and galactosylceramide by beta-galactosylceramidase (EC 3, 46), 6, 8), Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PSAP, Proactivator polypeptide, Prosaposin, SAP1, GLBA |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PSAP |
| Short name: |
PSAP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PSAP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9498 |
| Gene: |
PSAP |
More about : PSAP |
| Long gene name: |
prosaposin |
| Synonyms gene: |
SAP1 GLBA |
| Synonyms gene name: |
sphingolipid activator protein-1 |
| Synonyms name: |
variant Gaucher disease and variant metachromatic leukodystrophy |
| Locus: |
10q22, 1 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
BC004275 |
| Entrez gene record: |
5660 |
| Pubmed identfication: |
2717620 |
| RefSeq identity: |
NM_002778 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000018429 |