| Long name: |
HRP Conjugated, RORA Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
HRP Conjugated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
RORA |
| Specificity: |
This is a highly specific antibody against RORA |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
200-225/523 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic peptide derived from human ROR alpha |
| Gene ID number: |
6095 |
| Swiss Prot: |
P35398 |
| Tested applications: |
WB |
| Recommended dilutions: |
WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
APOA5, APOC3 and PPARG, ARNTL/BMAL1, CRY1 and NR1D1 itself, Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, Considered to have intrinsic transcriptional activity, In liver, Key regulator of embryonic development, NPAS2 and CRY1, OPN1SM and ARR3 and skeletal muscle development with MYOD1, Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, Regulates genes involved in photoreceptor development including OPN1SW, Regulates the circadian expression of several clock genes, Required for proper cerebellum development, Therefore influences the period length and stability of the clock, among others, cellular differentiation, circadian rhythm as well as lipid, depending on the tissue, enhancing or repressing the transcriptional activity, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), immunity, including CLOCK, leading to the circadian pattern of clock genes expression, regulates SHH gene expression, respectively, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, steroid, steroids and xenobiotics, such as CYP7B1 and SULT2A1, time and promoter contexts, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction, xenobiotics and glucose metabolism, Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
RZRA ROR1 ROR2 ROR3 NR1F1 |
| Properties: |
Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase |
| Gene target: |
RORA Conjugated |
| Short name: |
Conjugated, RORA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
HRP |
| Alternative name: |
horseradish peroxidase coupled, RAR-related orphan receptor A (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0006805 and xenobiotic metabolic process and biological process this GO :0006809 and nitric oxide biosynthetic process and biological process this GO :0007623 and circadian rhythm and biological process this GO :0008013 and beta-catenin binding and molecular function this GO :0008134 and transcription factor binding and molecular function this GO :0008142 and oxysterol binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008589 and regulation of smoothened signaling pathway and biological process this GO :0010467 and gene expression and biological process this GO :0010575 and positive regulation vascular endothelial growth factor production and biological process this GO :0010906 and regulation of glucose metabolic process and biological process this GO :0019218 and regulation of steroid metabolic process and biological process this GO :0021702 and cerebellar Purkinje cell differentiation and biological process this GO :0021930 and cerebellar granule cell precursor proliferation and biological process this GO :0030522 and intracellular receptor signaling pathway and biological process this GO :0032922 and circadian regulation of gene expression and biological process this GO :0036315 and cellular response to sterol and biological process this GO :0042692 and muscle cell differentiation and biological process this GO :0042752 and regulation of circadian rhythm and biological process this GO :0042753 and positive regulation of circadian rhythm and biological process this GO :0043030 and regulation of macrophage activation and biological process this GO :0043124 and negative regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043401 and steroid hormone mediated signaling pathway and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045599 and negative regulation of fat cell differentiation and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046068 and cGMP metabolic process and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0060850 and regulation of transcription involved in cell fate commitment and biological process this GO :0070328 and triglyceride homeostasis and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0072539 and T-helper 17 cell differentiation and biological process this GO :0098531 and direct ligand regulated sequence-specific DNA binding transcription factor activity and molecular function this GO :2000188 and regulation of cholesterol homeostasis and biological process, NR1F1 and ROR1 and ROR2 and ROR3 and RZR-ALPHA and RZRA, RORA and IDBG-14920 and ENSG00000069667 and 6095, RORA and IDBG-646570 and ENSBTAG00000015904 and 535597, Rora and IDBG-181478 and ENSMUSG00000032238 and 19883, direct ligand regulated sequence-specific DNA binding transcription factor activity, nuclei, this GO :0001222 and transcription corepressor binding and molecular function this GO :0001223 and transcription coactivator binding and molecular function this GO :0001525 and angiogenesis and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003707 and steroid hormone receptor activity and molecular function this GO :0004879 and ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0006351 and transcription, this GO :0001222 : transcription corepressor binding, this GO :0001222 : transcription corepressor binding and also this GO :0001223 : transcription coactivator binding and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003707 : steroid hormone receptor activity and also this GO :0004879 : ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008013 : beta-catenin binding and also this GO :0008134 : transcription factor binding and also this GO :0008142 : oxysterol binding and also this GO :0008270 : zinc ion binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0098531 : direct ligand regulated sequence-specific DNA binding transcription factor activity, this GO :0001223 : transcription coactivator binding, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003707 : steroid hormone receptor activity, this GO :0004879 : ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0005515 : protein binding, this GO :0008013 : beta-catenin binding, this GO :0008134 : transcription factor binding, this GO :0008142 : oxysterol binding, this GO :0008270 : zinc ion binding, this GO :0043565 : sequence-specific DNA binding, this GO :0098531 : direct ligand regulated sequence-specific DNA binding transcription factor activity, 790889, RAR-related orphan receptor A |
| Identity: |
10258 |
| Gene: |
RORA |
More about : RORA |
| Long gene name: |
RAR related orphan receptor A |
| Synonyms gene name: |
RAR-related orphan receptor A |
| Locus: |
15q22, 2 |
| Discovery year: |
1995-04-13 |
| GenBank acession: |
U04897 |
| Entrez gene record: |
6095 |
| Pubmed identfication: |
7926749 |
| RefSeq identity: |
NM_134261 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000132769 |