| Long name: |
KAT5 (Ser90) Primary Polyclonal Antibody |
| Also known as: |
KAT5 (Ser90) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
KAT5 |
| Specificity: |
This is a highly specific antibody against KAT5 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser90 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
80-99/513 |
| Subcellular location: |
Helical, Nucleus |
| Source: |
KLH conjugated synthesised phosphopeptide derived from human KAT5 around the phosphorylation site of Ser90 |
| Gene ID number: |
10524 |
| Swiss Prot: |
Q92993 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Component of a SWR1-like complex that specifically mediates the removal of histone H2A, Directly acetylates and activates ATM, In case of HIV-1 infection, NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage, Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565), Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2, This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription, and DNA repair, apoptosis, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation, tumor suppressor mediated growth arrest and replicative senescence, Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A, Z/H2AFZ from the nucleosome |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
60 kDa Tat-interactive protein, ESA1, HIV-1 Tat interactive protein, HTATIP, HTATIP1, Histone acetyltransferase HTATIP, Histone acetyltransferase KAT5, KAT5, Lysine acetyltransferase 5, PLIP, TIP60, ZC2HC5, cPLA(2)-interacting protein, cPLA2, TIP |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
KAT5 (Ser90) |
| Short name: |
KAT5 (Ser90) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
K(lysine) acetyltransferase 5 (Ser90) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006978 and DNA damage response, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050681 and androgen receptor binding and molecular function this GO :0070491 and repressing transcription factor binding and molecular function this GO :0071392 and cellular response to estradiol stimulus and biological process, KAT5 and IDBG-57604 and ENSG00000172977 and 10524, KAT5 and IDBG-644226 and ENSBTAG00000005578 and 505619, Kat5 and IDBG-132192 and ENSMUSG00000024926 and 81601, cPLA2 and ESA1 and HTATIP and HTATIP1 and PLIP and TIP and TIP60 and ZC2HC5, nuclei, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0010212 and response to ionizing radiation and biological process this GO :0016032 and viral process and biological process this GO :0016573 and histone acetylation and biological process this GO :0016747 and transferase activity, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000785 and chromatin and cellular component this GO :0000812 and Swr1 complex and cellular component this GO :0003713 and transcription coactivator activity and molecular function this GO :0004402 and histone acetyltransferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006302 and double-strand break repair and biological process this GO :0006325 and chromatin organization and biological process this GO :0006351 and transcription, this GO :0003713 : transcription coactivator activity, this GO :0003713 : transcription coactivator activity and also this GO :0004402 : histone acetyltransferase activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0016747 : transferase activity, this GO :0004402 : histone acetyltransferase activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0016747 : transferase activity, this GO :0032403 : protein complex binding, this GO :0046872 : metal ion binding, this GO :0050681 : androgen receptor binding, this GO :0070491 : repressing transcription factor binding, transferase activity, transferring acyl groups other than amino-acyl groups, transferring acyl groups other than amino-acyl groups and also this GO :0032403 : protein complex binding and also this GO :0046872 : metal ion binding and also this GO :0050681 : androgen receptor binding and also this GO :0070491 : repressing transcription factor binding, transferring acyl groups other than amino-acyl groups and molecular function this GO :0030521 and androgen receptor signaling pathway and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032703 and negative regulation of interleukin-2 production and biological process this GO :0032777 and Piccolo NuA4 histone acetyltransferase complex and cellular component this GO :0035267 and NuA4 histone acetyltransferase complex and cellular component this GO :0040008 and regulation of growth and biological process this GO :0043161 and proteasome-mediated ubiquitin-dependent protein catabolic process and biological process this GO :0043234 and protein complex and cellular component this GO :0045892 and negative regulation of transcription, K(lysine) acetyltransferase 5 |
| Identity: |
5275 |
| Gene: |
KAT5 |
More about : KAT5 |
| Long gene name: |
lysine acetyltransferase 5 |
| Synonyms gene: |
HTATIP |
| Synonyms gene name: |
60kDa K(lysine) acetyltransferase 5 , HIV-1 Tat interactive protein |
| Synonyms: |
TIP60 PLIP cPLA2 HTATIP1 ESA1 ZC2HC5 |
| Synonyms name: |
60kDa K-acetyltransferase 5 , Tat interacting protein |
| Locus: |
11q13, 1 |
| Discovery year: |
2000-04-13 |
| GenBank acession: |
U74667 |
| Entrez gene record: |
10524 |
| Pubmed identfication: |
8607265 |
| RefSeq identity: |
NM_006388 |
| Classification: |
Lysine acetyltransferases Zinc fingers C2HC-type |
| Havana BLAST/BLAT: |
OTTHUMG00000166617 |