| Long name: |
Cy7 Conjugated, Amyloid Precursor Protein(Y757) Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy7 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Amyloid Precursor Protein Tyr757 |
| Specificity: |
This phosphorylation site is homologous in the listed cross reactive species, This is a highly specific antibody against Amyloid Precursor Protein Tyr757 |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr757 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
730-770/770 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human APP around the phosphorylation site of Tyr757 |
| Gene ID number: |
351 |
| Swiss Prot: |
P05067 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts as a kinesin I membrane receptor, Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses, Beta-amyloid 42 is a more effective reductant than beta-amyloid 40, Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity, Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, Bind transient metals such as copper, Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb, Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV, Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP, In vitro, In vitro, Induces a AGER-dependent pathway that involves activation of p38 MAPK, Inhibits G(o) alpha ATPase activity (By similarity), Involved in cell mobility and transcription regulation through protein-protein interactions, Involved in copper homeostasis/oxidative stress through copper ion reduction, Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1, The splice isoforms that contain the BPTI domain possess protease inhibitor activity, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation, inhibiting metal-catalyzed oxidation of lipoproteins, mediating the axonal transport of beta-secretase and presenilin 1, neuronal adhesion and axonogenesis, respectively, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons, zinc and iron, Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
743nm/767nm |
| Synonyms: |
A4, ABETA, ABPP, AD1, APP, APPI, Alzheimer disease amyloid protein, Amyloid beta A4 protein, CTFgamma, CVAP, Cerebral vascular amyloid peptide, PN-II, PN2, PreA4, Protease nexin-II, AAA |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths |
| Description: |
also called a , is a type of partially differentiated, usually , Precursor cell, blast, blast cell , cell that has lost most or all of the , multipotency, or simply , stem cell , unipotent |
| Gene target: |
Amyloid Precursor Protein(Y757) Conjugated |
| Short name: |
Conjugated, Amyloid Protein(Y757) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy7 |
| Alternative name: |
cyanine 7 coupled, Amyloid Precursor Protein(Y757) (Antibody to) |
| Alternative technique: |
antibodies |