| Long name: |
ALEXA FLUOR 488 Conjugated, CHIP Polyclonal Antibody |
| Also known as: |
Anti-CHIP PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CHIP |
| Specificity: |
This is a highly specific antibody against CHIP |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
120-170/303 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CHIP |
| Gene ID Number: |
10273 |
| Swiss Prot: |
Q9UNE7 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
'Lys-61' and 'Lys-81', Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension, Hsc70 and Hsp90, Mediates polyubiquitination of CYP3A4, Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation, Modulates the activity of several chaperone complexes, Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223), Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation, Ubiquitinates NOS1 in concert with Hsp70 and Hsp40, including Hsp70, thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome, E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
Antigen NY-CO-7, CLL-associated antigen KW-8, Carboxy terminus of Hsp70-interacting protein, E3 ubiquitin-protein ligase CHIP, HSPABP2, NY-CO-7, PP1131, SCAR16, SDCCAG7, STIP1 homology and U box-containing protein 1, STUB1, UBOX1, CHIP |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the CHIP Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Short name: |
CHIP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, CHIP (Antibody to) |
| Alternative technique: |
antibodies |