| Long name: |
CD22/BLCAM Primary Polyclonal Antibody |
| Also known as: |
CD22/BLCAM PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CD22/BLCAM |
| Specificity: |
This is a highly specific antibody against CD22/BLCAM |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
710-760/847 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CD22 |
| Gene ID number: |
933 |
| Swiss Prot: |
P20273 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Binds sialylated glycoproteins, May be involved in the localization of B-cells in lymphoid tissues, Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules, Preferentially binds to alpha-2, The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface, Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling, one of which is CD45, 6-linked sialic acid, Mediates B-cell B-cell interactions |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, CD22, SIGLEC-2, Sialic acid-binding Ig-like lectin 2, T-cell surface antigen Leu-14, SIGLEC2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CD22/BLCAM |
| Short name: |
CD22/BLCAM Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CD22 molecule/BLCAM (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD22 and IDBG-44001 and ENSG00000012124 and 933, CD22 and IDBG-635610 and ENSBTAG00000011887 and 514582, Cd22 and IDBG-171574 and ENSMUSG00000030577 and 12483, Cell surfaces, SIGLEC-2 and SIGLEC2, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0045087 and innate immune response and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005515 : protein binding, this GO :0005515 : protein binding, CD22 molecule |
| Identity: |
1643 |
| Gene: |
CD22 |
More about : CD22 |
| Long gene name: |
CD22 molecule |
| Synonyms gene name: |
CD22 antigen |
| Synonyms: |
SIGLEC-2 SIGLEC2 |
| Synonyms name: |
sialic acid binding Ig-like lectin 2 |
| Locus: |
19q13, 12 |
| Discovery year: |
1991-06-06 |
| GenBank acession: |
X52785 |
| Entrez gene record: |
933 |
| Pubmed identfication: |
8496602 1691828 |
| RefSeq identity: |
NM_001771 |
| Classification: |
C2-set domain containing CD molecules Sialic acid binding Ig like lectins |
| Havana BLAST/BLAT: |
OTTHUMG00000183298 |