| Long name: |
PDI Primary Polyclonal Antibody |
| Also known as: |
PDI PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PDI |
| Specificity: |
This is a highly specific antibody against PDI |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PDI |
| Gene ID number: |
2923 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
PDI, Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively), The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER, This retention is reported to be mediated by a KDEL receptor, as well as the reduction of disulphide bonds in proteins, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds, which catalyses disulphide interchange between thiols and protein dilsulphides, The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ERBA2L, ERp57, ERp60, ERp61, Erp, Grp58, P4HB, PDI, PDI-Q2, PDIA1, PDIA1_HUMAN, PDIP, PI-PLC, PLC[a], PO4DB, Pancreatic protein disulfide isomerase, Pdia3, Plca, Protein disulfide isomerase, Protein disulfide isomerase A2, Protein disulfide isomerase family A member 2, Protein Disulfide lsomerase |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PDI |
| Short name: |
PDI Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PDI (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
18367 |
| Gene: |
PADI1 |
More about : PADI1 |
| Long gene name: |
peptidyl arginine deiminase 1 |
| Synonyms gene name: |
peptidyl arginine deiminase, type I |
| Synonyms: |
HPAD10 PDI1 PDI PAD1 |
| Synonyms name: |
peptidylarginine deiminase type I protein-arginine deiminase type-1 hPAD-colony 10 |
| Locus: |
1p36, 13 |
| Discovery year: |
2002-03-12 |
| GenBank acession: |
AB033768 |
| Entrez gene record: |
29943 |
| Pubmed identfication: |
12416996 |
| RefSeq identity: |
NM_013358 |
| Classification: |
Peptidyl arginine deiminases |
| Havana BLAST/BLAT: |
OTTHUMG00000002294 |