| Long name: |
FITC Conjugated, SLUG Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SLUG |
| Specificity: |
This is a highly specific antibody against SLUG |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
1-50/268 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human Slug |
| Gene ID number: |
6591 |
| Swiss Prot: |
O43623 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts, Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes, Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, In epidermal keratinocytes, Involved in osteoblast maturation, Involved in the generation and migration of neural crest cells, Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes, Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis, Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells, Represses E-Cadherin/CDH1 transcription via E-box elements, binds to the E-box in ITGA3 promoter and represses its transcription, in osteoblasts, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity), respectively, Transcriptional repressor that modulates both activator-dependent and basal transcription |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
SLUGH1 SNAIL2 SLUGH |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SLUG Conjugated |
| Short name: |
FITC Conjugated, SLUG Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, SLUG (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11094 |
| Gene: |
SNAI2 |
More about : SNAI2 |
| Long gene name: |
snail family transcriptional repressor 2 |
| Synonyms gene: |
SLUG |
| Synonyms gene name: |
slug homolog, zinc finger protein (chicken) snail homolog 2 (Drosophila) snail family zinc finger 2 |
| Locus: |
8q11, 21 |
| Discovery year: |
1998-07-03 |
| GenBank acession: |
U97060 |
| Entrez gene record: |
6591 |
| Pubmed identfication: |
9337409 9721220 |
| RefSeq identity: |
NM_003068 |
| Classification: |
Zinc fingers C2H2-type SNAG transcriptional repressors |
| Havana BLAST/BLAT: |
OTTHUMG00000149912 |