| Long name: |
ALEXA FLUOR 647 Conjugated, SLUG Polyclonal Antibody |
| Also known as: |
Anti-SLUG PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SLUG |
| Specificity: |
This is a highly specific antibody against SLUG |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1-50/268 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Slug |
| Gene ID Number: |
6591 |
| Swiss Prot: |
O43623 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts, Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes, Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, In epidermal keratinocytes, Involved in osteoblast maturation, Involved in the generation and migration of neural crest cells, Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes, Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis, Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells, Represses E-Cadherin/CDH1 transcription via E-box elements, binds to the E-box in ITGA3 promoter and represses its transcription, in osteoblasts, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity), respectively, Transcriptional repressor that modulates both activator-dependent and basal transcription |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
SLUGH1 SNAIL2 SLUGH |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the SLUG Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
SLUG |
| Short name: |
SLUG Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, SLUG (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11094 |
| Gene: |
SNAI2 |
More about : SNAI2 |
| Long gene name: |
snail family transcriptional repressor 2 |
| Synonyms gene: |
SLUG |
| Synonyms gene name: |
slug homolog, zinc finger protein (chicken) snail homolog 2 (Drosophila) snail family zinc finger 2 |
| Locus: |
8q11, 21 |
| Discovery year: |
1998-07-03 |
| GenBank acession: |
U97060 |
| Entrez gene record: |
6591 |
| Pubmed identfication: |
9337409 9721220 |
| RefSeq identity: |
NM_003068 |
| Classification: |
Zinc fingers C2H2-type SNAG transcriptional repressors |
| Havana BLAST/BLAT: |
OTTHUMG00000149912 |