| Long name: |
AKAP12/Gravin Primary Polyclonal Antibody |
| Also known as: |
AKAP12/Gravin PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
AKAP12/Gravin |
| Specificity: |
This is a highly specific antibody against AKAP12/Gravin |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human of human AKAP12 |
| Gene ID number: |
9590 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
AKAP12) was cloned from a cDNA expression library screened with serum, Decreased binding of PKCa to gravin was found after activation of PKC, Gravin can bind kinases like PKA and PKC by different domains of the protein and can localize these kinases to specific domains in the cell, Gravin expression is up regulated and enriched at the inner peripheral cortex in close proximity to the plasma membrane, In differentiated cells, PKCa and PKA, This protein is a myristoylated high molecular weight cytoplasmic protein expressed in endothelial cells, Upon differentiation of NT2 cells to neurons (NT2 N), cultured fibroblasts and osteosarcoma cells and highly expressed in the brain, from a myasthenia gravis patient, gravin is co-localized with PKCbII, to Gravin were found in 22 out of 72 myasthemia gravis patients and absent in sera of normal individuals, Gravin (also known as A Kinase Anchor Protein 12 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
A kinase Anchor Protein 12, A kinase anchor protein 250kDa, AKAP 12, AKAP 250, AKAP250, DKFZp686M0430, DKFZp686O0331, Gercelin, Gravin, Kinase scaffold protein gravin, Myasthenia gravis autoantigen gravin, SSeCKS, Srcs5, Tsga12, A kinase PRKA anchor protein gravin 12 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
AKAP12/Gravin |
| Short name: |
AKAP12/Gravin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
AKAP12/Gravin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
370 |
| Gene: |
AKAP12 |
More about : AKAP12 |
| Long gene name: |
A-kinase anchoring protein 12 |
| Synonyms gene name: |
A kinase (PRKA) anchor protein (gravin) 12 A kinase (PRKA) anchor protein 12 |
| Synonyms: |
AKAP250 SSeCKS |
| Synonyms name: |
gravin Src-Suppressed C Kinase Substrate |
| Locus: |
6q25, 1 |
| Discovery year: |
1999-09-16 |
| GenBank acession: |
U81607 |
| Entrez gene record: |
9590 |
| Pubmed identfication: |
9000000 |
| Classification: |
A-kinase anchoring proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000015833 |