| Long name: |
Biotin Conjugated, GPR30 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
GPR30 |
| Specificity: |
This is a highly specific antibody against GPR30 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
320-360/375 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human GPR30 |
| Gene ID number: |
2852 |
| Swiss Prot: |
Q99527 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Associated with EGFR, Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules, Contributes to thymic atrophy by inducing apoptosis, Enhances uterine contractility in response to oxytocin, Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway, Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner, Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons, Inhibits early osteoblast proliferation at growth plate during skeletal development, Inhibits mature adipocyte differentiation and lipid accumulation, Involved in cancer progression regulation, Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells, Mediates pleiotropic functions among others in the cardiovascular, Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death, Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells, Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells, Promotes neuritogenesis in developing hippocampal neurons, Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation, Stimulates cAMP production, Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway, Stimulates uterine epithelial cell proliferation, Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation, activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), cyclin D1), endocrine, immune and central nervous systems, leading to rapid and transient activation of numerous intracellular signaling pathways, may act as a transcription factor activating growth regulatory genes (c-fos, reproductive, G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
FEG-1 GPCR-Br LERGU LERGU2 DRY12 LyGPR CEPR |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GPR30 Conjugated |
| Short name: |
Conjugated, GPR30 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, GPR30 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4485 |
| Gene: |
GPER1 |
More about : GPER1 |
| Long gene name: |
G protein-coupled estrogen receptor 1 |
| Synonyms gene: |
CMKRL2 GPR30 GPER |
| Synonyms gene name: |
G protein-coupled receptor 30 |
| Locus: |
7p22, 3 |
| Discovery year: |
1997-06-12 |
| GenBank acession: |
U63917 |
| Entrez gene record: |
2852 |
| Pubmed identfication: |
9479505 17655271 |
| RefSeq identity: |
NM_001039966 |
| Classification: |
G protein-coupled estrogen receptor |
| Havana BLAST/BLAT: |
OTTHUMG00000023680 |