| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
EDNRB |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the EDNRB antibody should be determined by the researcher |
| Intented use: |
This EDNRB antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P24530 |
| Purity: |
Antigen affinity |
| Description: |
Alternatively spliced transcript variants encoding different isoforms have been found for this gene, ET2, Hirschsprung disease type 2, Its ligand, Studies suggest that the multigenic disorder, The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system, also known as ETB, and ET3, consists of a family of three potent vasoactive peptides: ET1, endothelin, is a protein that in humans is encoded by the EDNRB gene, is due to mutations in the endothelin receptor type B gene, Endothelin receptor type B |
| Immunogen: |
Amino acids QSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKY of human EDNRB were used as the immunogen for the EDNRB antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the EDNRB antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
membrane, Cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
EDNRB |
| Short name: |
EDNRB Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
endothelin receptor classification B (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ABCDS and ET-B and ET-BR and ETB and ETBR and ETRB and HSCR and HSCR2 and WS4A, EDNRB and IDBG-40388 and ENSG00000136160 and 1910, EDNRB and IDBG-631994 and ENSBTAG00000005299 and 281750, Ednrb and IDBG-185332 and ENSMUSG00000022122 and 13618, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001755 and neural crest cell migration and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004962 and endothelin receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006885 and regulation of pH and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007194 and negative regulation of adenylate cyclase activity and biological process this GO :0007200 and phospholipase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007399 and nervous system development and biological process this GO :0007422 and peripheral nervous system development and biological process this GO :0007497 and posterior midgut development and biological process this GO :0007568 and aging and biological process this GO :0008217 and regulation of blood pressure and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0014043 and negative regulation of neuron maturation and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0014826 and vein smooth muscle contraction and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0017046 and peptide hormone binding and molecular function this GO :0019233 and sensory perception of pain and biological process this GO :0019934 and cGMP-mediated signaling and biological process this GO :0030318 and melanocyte differentiation and biological process this GO :0031620 and regulation of fever generation and biological process this GO :0031702 and type 1 angiotensin receptor binding and molecular function this GO :0031965 and nuclear membrane and cellular component this GO :0032269 and negative regulation of cellular protein metabolic process and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0035645 and enteric smooth muscle cell differentiation and biological process this GO :0035810 and positive regulation of urine volume and biological process this GO :0035815 and positive regulation of renal sodium excretion and biological process this GO :0042045 and epithelial fluid transport and biological process this GO :0042310 and vasoconstriction and biological process this GO :0042311 and vasodilation and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043473 and pigmentation and biological process this GO :0045121 and membrane raft and cellular component this GO :0048066 and developmental pigmentation and biological process this GO :0048246 and macrophage chemotaxis and biological process this GO :0048265 and response to pain and biological process this GO :0048484 and enteric nervous system development and biological process this GO :0050678 and regulation of epithelial cell proliferation and biological process this GO :0051930 and regulation of sensory perception of pain and biological process this GO :0060406 and positive regulation of penile erection and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0086100 and endothelin receptor signaling pathway and biological process, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0004962 : endothelin receptor activity and also this GO :0005515 : protein binding and also this GO :0017046 : peptide hormone binding and also this GO :0031702 : type 1 angiotensin receptor binding, this GO :0004962 : endothelin receptor activity, this GO :0005515 : protein binding, this GO :0017046 : peptide hormone binding, this GO :0031702 : type 1 angiotensin receptor binding, type 1 angiotensin receptor binding, endothelin receptor type B |
| Identity: |
3180 |
| Gene: |
EDNRB |
More about : EDNRB |
| Long gene name: |
endothelin receptor type B |
| Synonyms gene: |
HSCR2 HSCR |
| Synonyms: |
ETB |
| Locus: |
13q22, 3 |
| Discovery year: |
1992-02-13 |
| GenBank acession: |
L06623 |
| Entrez gene record: |
1910 |
| Pubmed identfication: |
1659806 9556633 |
| Classification: |
Endothelin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000017111 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database |