| Also known as: |
NOTCH 2 |
| Other names: |
Motch B, Motch B, Neurogenic locus notch homolog protein 2, Notch gene homolog 2, neurogenic locus notch homolog protein 2, notch 2, neurogenic locus notch homolog protein 2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
NOTCH 2 |
| Other gene names: |
AI853703, N2, Notch 2, Notch2, Notch2 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG |
| Clone: |
HMN2-35 |
| Host organism: |
Hamster |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
DLL3 and DLL4, Delta-like protein 1 (DLL1), Jagged1 (CD339), Jagged2, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have also shown a correlation between a decrease in Notch 2 expression and an increase in grade of human breast cancer, Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), The canonical pathway inhibits the differentiation of stem cells or progenitor cells, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Clone HMN2-35 has been shown to cross-react with rat mast cell line RBL-2H3 and Y3 myeloma cells, _x000D__x000D_Ligation of Notch receptors by their specific ligands, _x000D__x000D_Signaling through Notch 2 has been implicated in the development of marginal zone B cells (MZB), _x000D__x000D_The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, and both tumor progression and suppression, and the regulation of the expression of CD23 in B-cell lymphocytic leukemia (B-CLL), cardiac and endocrine development, important during fundamental developmental and physiological processes, in flow cytometry, including regulation of cell fate decisions during neuronal, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, on physically adjacent signal receiving cells, one of the four major transmembrane receptors (Notch 1-4) of the Notch signaling pathway, or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway), releasing the Notch intracellular domain (NICD) to translocate to the nucleus, stem cell hematopoiesis, the sensitization of endothelial cells to apoptosis, thymic T-cell development, which is activated through binding to DSL domain-containing membrane-bound specific ligands, which is vital for cell-cell communication, whilst the non-canonical pathway promotes differentiation, within the transmembrane domain, NOTCH 2 This item specifically recognises Notch 2 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
NOTCH 2 |
| Short name: |
HAMSTER ANTI MOUSE NOTCH 2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HAMSTER antibody to MOUSE NOTCH 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
31862 |
| Gene: |
NOTCH2NL |
More about : NOTCH2NL |
| Long gene name: |
notch 2 N-terminal like |
| Synonyms gene name: |
Notch homolog 2 (Drosophila) N-terminal like |
| Synonyms: |
N2N |
| Locus: |
1q21, 1 |
| Discovery year: |
2004-12-02 |
| Entrez gene record: |
388677 |
| Pubmed identfication: |
14673143 |
| RefSeq identity: |
NM_203458 |
| Havana BLAST/BLAT: |
OTTHUMG00000013754 |