| Also known as: |
CD300a |
| Other names: |
CD300 antigen-like family member A, CD300 antigen-like family member A, CD300a antigen, CD300a molecule, CMRF-35-H9, CMRF35-H, CMRF35-H9, CMRF35-like molecule 8, CMRF35-like molecule 8, CMRF35H leukocyte immunoglobulin-like receptor, IRC1/IRC2, IRp60, IgSF12, Immunoglobulin superfamily member 12, Inhibitory receptor protein 60, NK inhibitory receptor, NK inhibitory receptor, immunoglobulin superfamily member 12, inhibitory receptor protein 60, leukocyte membrane antigen, CMRF35-like molecule 8 isoform 2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD300a |
| Other gene names: |
CD300A, CLM-8, CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, CMRF35-H9, CMRF35-H9, CMRF35H, CMRF35H, CMRF35H9, IGSF12, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60, IRp60, IgSF12, CD300A |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
MEM-260 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Furthermore, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, T and B cell subsets, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, a 60kDa transmembrane glycoprotein expressed by natural killer cells (NK), can down-regulate CD300a expression on mast cells <, chemotaxis and activation in response to certain inflammatory cytokines, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, dendritic cells (DC) and mast cells, granulocytes, inhibits IgE-induced degranulation and SCF-mediated survival, macrophages, monocytes, neutrophils, otherwise known as IRp60 (inhibitory receptor protein 60), whilst cross-linking of CD300a on mast cells, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), /i>, CD300a This item specifically recognises human CD300a, i>, in vitro< |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Western Blot (WB), Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD300a |
| Short name: |
MOUSE Anti-HUMAN CD300a Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD300a molecule (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
19319 |
| Gene: |
CD300A |
More about : CD300A |
| Long gene name: |
CD300a molecule |
| Synonyms gene name: |
CD300a antigen |
| Synonyms: |
Irp60 CMRF35H CMRF-35-H9 IRC1 IRC2 IGSF12 |
| Locus: |
17q25, 1 |
| Discovery year: |
2005-02-08 |
| GenBank acession: |
BC032352 |
| Entrez gene record: |
11314 |
| Pubmed identfication: |
9701027 10746781 |
| RefSeq identity: |
NM_007261 |
| Classification: |
CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000067612 |