| Also known as: |
CD86 |
| Other names: |
Activation B7-2 antigen, CD86 antigen, Early T-cell costimulatory molecule 1, T-lymphocyte activation antigen CD86, T-lymphocyte activation antigen CD86, activation B7-2 antigen, early T cell costimulatory molecule-1, early T-cell costimulatory molecule 1, T-lymphocyte activation antigen CD86 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD86 |
| Other gene names: |
B7, B7, B7-2, B70, CLS1, Cd28l2, Cd86, ETC-1, ETC-1, Ly-58, Ly58, MB7, MB7-2, TS/A-2, 2, Cd86 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2b |
| Clone: |
PO3 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
CD28 and CTLA4 are two receptors that have opposing functions in T-cell stimulation, CD86 has been identified, CD86 is expressed at high levels on peripheral blood monocytes, Expression of CD86 on these cell populations can be increased upon activation, In mouse, Interaction of CD86 with CD28 promotes a number of T-cell activities, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The PO3 clone has been reported to block some co-stimulatory functions of CD86, This particular antibody might cross react with speacies outside of the listed ones, along with CD80 (B7-1) as a ligand for CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA4), an 80kD cell surface glycoprotein which is a member of the CD28/B7 family, dendritic cells and at low levels on resting B and T-lymphocytes, whereas the binding of CD86 to CTLA4 inhibits T-cell responses, CD86 This item recognises mouse CD86 (B7-2) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD86 |
| Short name: |
RAT ANTI MOUSE CD86 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE CD86 molecule (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
B7-2 and B7, CD86 and IDBG-52336 and ENSG00000114013 and 942, CD86 and IDBG-633264 and ENSBTAG00000013118 and 414345, Cd86 and IDBG-158071 and ENSMUSG00000022901 and 12524, Cell surfaces, DNA-templated and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0051607 and defense response to virus and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071248 and cellular response to metal ion and biological process this GO :0071345 and cellular response to cytokine stimulus and biological process, coreceptor activity, this GO :0001878 and response to yeast and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002309 and T cell proliferation involved in immune response and biological process this GO :0002668 and negative regulation of T cell anergy and biological process this GO :0004872 and receptor activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007568 and aging and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0015026 and coreceptor activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0031295 and T cell costimulation and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0034341 and response to interferon-gamma and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042104 and positive regulation of activated T cell proliferation and biological process this GO :0042110 and T cell activation and biological process this GO :0042113 and B cell activation and biological process this GO :0042493 and response to drug and biological process this GO :0043011 and myeloid dendritic cell differentiation and biological process this GO :0043017 and positive regulation of lymphotoxin A biosynthetic process and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0045086 and positive regulation of interleukin-2 biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045404 and positive regulation of interleukin-4 biosynthetic process and biological process this GO :0045630 and positive regulation of T-helper 2 cell differentiation and biological process this GO :0045893 and positive regulation of transcription, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0005102 : receptor binding and also this GO :0005515 : protein binding and also this GO :0015026 : coreceptor activity, this GO :0005102 : receptor binding, this GO :0005515 : protein binding, this GO :0015026 : coreceptor activity, 2 and B70 and CD28LG2 and LAB72, CD86 molecule |
| Identity: |
1705 |
| Gene: |
CD86 |
More about : CD86 |
| Long gene name: |
CD86 molecule |
| Synonyms gene: |
CD28LG2 |
| Synonyms gene name: |
B7-2 antigen) , CD86 antigen (CD28 antigen ligand 2 |
| Synonyms: |
B7, 2 B7-2 |
| Synonyms name: |
B-lymphocyte antigen B7-2 |
| Locus: |
3q13, 33 |
| Discovery year: |
1994-12-07 |
| Entrez gene record: |
942 |
| Pubmed identfication: |
7513726 |
| RefSeq identity: |
NM_006889 |
| Classification: |
Immunoglobulin like domain containing CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000159482 |