| Long name: |
Biotin Conjugated, Guanylyl Cyclase alpha 2 Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Guanylyl Cyclase alpha 2 |
| Specificity: |
This is a highly specific antibody against Guanylyl Cyclase alpha 2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Guanylyl Cyclase alpha 2 |
| Gene ID number: |
2977 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, Both alpha and beta subunits are required for cGMP generation, GCS is a cGMP-synthesizing enzyme, GCS is a heme-containing heterodimer, Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, It plays a crucial role in smooth muscle contractility, The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, The heme moeity mediates NO activation, The membrane-bound receptor form, The soluble form, There are two forms of guanylate cyclase, YC-1, YC-1 can also stimulate GCS in a NO-independent manner, act as receptors for nitric oxide (NO), and at least two isoforms exist for each subunit, and both display similar enzymatic activity, and this heme group also binds carbon monoxide (CO), are peptide hormone receptors, consisting of one alpha subunit and one beta subunit, known as GC, known as GCS or sGC, platelet reactivity and neurotransmission, which is the major receptor for the neurotransmitter nitric oxide, which weakly stimulates the enzyme, with predominant expression in kidney and liver, Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
GCS-alpha 2, GCYA2_HUMAN, GUC1A2, GUCSA2, GC SA2 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Guanylyl Cyclase alpha 2 Conjugated |
| Short name: |
Conjugated, Guanylyl Cyclase alpha 2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, Guanylyl Cyclase a 2 (Antibody to) |
| Alternative technique: |
antibodies |