| Long name: |
Cy5, 5 Conjugated, FANCC Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FANCC |
| Specificity: |
This is a highly specific antibody against FANCC |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human FANCC |
| Gene ID number: |
2176 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4, Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, FANCC is expressed in a cell cycle-dependent manner, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8), In addition, In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7, The FA Group C complementation group gene encodes the protein FANCC, The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3), These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8), birth defects and chromsomal instability (1, which is a transcriptional repressor (6), which is located in both cytoplasmic and nuclear compartments, which suggests that FANCC indirectly suppresses the activity of PKR, with the lowest levels at the G1/S boundary and the highest levels in the M-phase, 2), 5), 8), Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
FAC FA3 |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
FANCC Conjugated |
| Short name: |
Conjugated, FANCC Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
complementation family C (Antibody to), cyanine 5, 5 coupled, Fanconi anemia |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
FA3 and FAC and FACC, FANCC and IDBG-636496 and ENSBTAG00000017195 and 281762, FANCC and IDBG-77041 and ENSG00000158169 and 2176, Fancc and IDBG-160833 and ENSMUSG00000021461 and 14088, complementation group C, nuclei, protein binding, this GO :0002262 and myeloid cell homeostasis and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006281 and DNA repair and biological process this GO :0006289 and nucleotide-excision repair and biological process this GO :0006461 and protein complex assembly and biological process this GO :0007276 and gamete generation and biological process this GO :0007281 and germ cell development and biological process this GO :0019430 and removal of superoxide radicals and biological process this GO :0043240 and Fanconi anaemia nuclear complex and cellular component this GO :0045087 and innate immune response and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, Fanconi anemia |
| Identity: |
3584 |
| Gene: |
FANCC |
More about : FANCC |
| Long gene name: |
Fanconi anemia complementation group C |
| Synonyms gene: |
FACC |
| Locus: |
9q22, 32 |
| Discovery year: |
1992-11-25 |
| GenBank acession: |
BC006303 |
| Entrez gene record: |
2176 |
| Pubmed identfication: |
1303234 |
| RefSeq identity: |
NM_000136 |
| Classification: |
Fanconi anemia complementation groups |
| Havana BLAST/BLAT: |
OTTHUMG00000020279 |
| Locus Specific Databases: |
Fanconi Anaemia Mutation Database Fanconi anemia database LRG_497 |