| Long name: |
Cy5 Conjugated, TLE4 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TLE4 |
| Specificity: |
This is a highly specific antibody against TLE4 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human TLE4 |
| Gene ID number: |
7091 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Expression of the TLE genes, Groucho is a transcriptional repressor that plays a key role in neurogenesis, In early stages of cell differentiation, In later stages, Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, TLE1, TLE1, TLE1 and TLE4 contain SP and WD40 domains, TLE1 is upregulated, TLE2, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, TLE2 and TLE4 are upregulated, TLE3 and TLE4, TLEs associate with chromatin in live cells and specifically with Histone H3, also designated ESG for enhancer of split groucho), and TLE2 and TLE4 are downregulated, and expression of TLE1 decreases, but not with other core histones, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, particularly in the caudate nucleus, segmentation and sex determination, suggesting a role during epithelial differentiation, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor, which are human homologs of the Drosophila groucho gene, while TLE4 is most highly expressed in the brain, The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
625, 650nm/670nm |
| Synonyms: |
E(spI) ESG GRG4 |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TLE4 Conjugated |
| Short name: |
Conjugated, TLE4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy5 |
| Alternative name: |
cyanine 5 coupled, TLE4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11840 |
| Gene: |
TLE4 |
More about : TLE4 |
| Long gene name: |
transducin like enhancer of split 4 |
| Synonyms gene name: |
Drosophila) , transducin-like enhancer of split 4 (E(sp1) homolog |
| Locus: |
9q21, 31 |
| Discovery year: |
1993-12-20 |
| GenBank acession: |
M99439 |
| Entrez gene record: |
7091 |
| Pubmed identfication: |
8365415 |
| RefSeq identity: |
XM_212237 |
| Classification: |
WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000020072 |