| Long name: |
ALEXA FLUOR 647 Conjugated, TLE4 Polyclonal Antibody |
| Also known as: |
Anti-TLE4 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TLE4 |
| Specificity: |
This is a highly specific antibody against TLE4 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TLE4 |
| Gene ID Number: |
7091 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Expression of the TLE genes, Groucho is a transcriptional repressor that plays a key role in neurogenesis, In early stages of cell differentiation, In later stages, Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, TLE1, TLE1, TLE1 and TLE4 contain SP and WD40 domains, TLE1 is upregulated, TLE2, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, TLE2 and TLE4 are upregulated, TLE3 and TLE4, TLEs associate with chromatin in live cells and specifically with Histone H3, also designated ESG for enhancer of split groucho), and TLE2 and TLE4 are downregulated, and expression of TLE1 decreases, but not with other core histones, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, particularly in the caudate nucleus, segmentation and sex determination, suggesting a role during epithelial differentiation, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor, which are human homologs of the Drosophila groucho gene, while TLE4 is most highly expressed in the brain, The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
E(spI) ESG GRG4 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the TLE4 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
TLE4 |
| Short name: |
TLE4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, TLE4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11840 |
| Gene: |
TLE4 |
More about : TLE4 |
| Long gene name: |
transducin like enhancer of split 4 |
| Synonyms gene name: |
Drosophila) , transducin-like enhancer of split 4 (E(sp1) homolog |
| Locus: |
9q21, 31 |
| Discovery year: |
1993-12-20 |
| GenBank acession: |
M99439 |
| Entrez gene record: |
7091 |
| Pubmed identfication: |
8365415 |
| RefSeq identity: |
XM_212237 |
| Classification: |
WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000020072 |