| Long name: |
ALEXA FLUOR 594 Conjugated, NLE1 Polyclonal Antibody |
| Also known as: |
Anti-NLE1 PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NLE1 |
| Specificity: |
This is a highly specific antibody against NLE1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NLE1 |
| Gene ID Number: |
54475 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Deletion of the NLE1 gene in mice during the early stages of development results in embryonic death, In plants, It may also play a role in 60S ribosomal subunit biogenesis in yeast, NLE1 contains eight WD40 domains and produces one isoform due to alternative splicing, NLE1 is a 485 amino acid WD40-repeat protein that binds to the cytoplasmic domain of Notch, NLE1 is crucial for normal cellular growth and development, Notch receptors play an important role in development and cell-fate decisions, Notchless is a loss-of-function mutant allele that encodes for protein NLE1 (notchless homolog 1), Under-expression during shoot proliferation causes pleiotropic defects such as delayed flowering and abnormal organ maturation, regulating its signaling activity in Drosophila melanogaster and in mice, while gene deletion in the late stages of development leads to activation of a caspase-3-dependent apoptotic pathway, The Notch signaling pathway is an evolutionary conserved system that is involved in intracellular communication |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FLJ10458 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
NLE1 |
| Short name: |
NLE1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, NLE1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
19889 |
| Gene: |
NLE1 |
More about : NLE1 |
| Long gene name: |
notchless homolog 1 |
| Synonyms gene name: |
notchless homolog 1 (Drosophila) |
| Synonyms name: |
(Drosophila) , Notchless gene homolog |
| Locus: |
17q12 |
| Discovery year: |
2005-05-24 |
| Entrez gene record: |
54475 |
| RefSeq identity: |
NM_018096 |
| Classification: |
WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000132928 |