| Long name: |
TAZ Primary Polyclonal Antibody |
| Also known as: |
TAZ PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TAZ |
| Specificity: |
This is a highly specific antibody against TAZ |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
15-70/400 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TAZ |
| Gene ID number: |
25937 |
| Swiss Prot: |
Q9GZV5 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Regulates embryonic stem-cell self-renewal, Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, promotes cell proliferation and epithelial-mesenchymal transition, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Transcriptional coactivator with PDZ-binding motif, WW domain-containing transcription regulator protein 1, WWTR1, TAZ |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TAZ |
| Short name: |
TAZ Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TAZ (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
24042 |
| Gene: |
WWTR1 |
More about : WWTR1 |
| Long gene name: |
WW domain containing transcription regulator 1 |
| Synonyms: |
TAZ DKFZp586I1419 |
| Locus: |
3q25, 1 |
| Discovery year: |
2004-12-03 |
| GenBank acession: |
AK022036 |
| Entrez gene record: |
25937 |
| Pubmed identfication: |
11118213 15096513 |
| RefSeq identity: |
NM_015472 |
| Havana BLAST/BLAT: |
OTTHUMG00000159614 |