| Long name: |
ALEXA FLUOR 555 Conjugated, KALRN/Duo Polyclonal Antibody |
| Also known as: |
Anti-KALRN/Duo PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
KALRN/Duo |
| Specificity: |
This is a highly specific antibody against KALRN/Duo |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KALRN/Duo |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Duo, HAP1 is primarily expressed in brain tissue, HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4, Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, Mouse HAP1 is localized to membrane-bound organelles including large endosomes, The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1), also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function, the gene encodes a version of huntingtin that leads to Huntingtonâ, tubulovesicular structures and budding vesicles in neurons (6), with greater expression in the olfactory bulb and brain stem (1), &euro, &trade, 3), 5), HAP1 (huntingtin-associated protein 1) binds to huntingtin (1), s disease (HD) (2 |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
duo Hs, 8004 TRAD DUET Kalirin ARHGEF24 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
KALRN/Duo |
| Short name: |
KALRN/Duo Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, RhoGEF kinase/Duo (Antibody to), kalirin |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ARHGEF24 and CHD5 and CHDS5 and DUET and DUO and HAPIP and TRAD, Cytoplasm, KALRN and IDBG-53661 and ENSG00000160145 and 8997, KALRN and IDBG-633466 and ENSBTAG00000002640 and 540675, Kalrn and IDBG-155984 and ENSMUSG00000061751 and 545156, RhoGEF kinase, this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005089 and Rho guanyl-nucleotide exchange factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007399 and nervous system development and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016192 and vesicle-mediated transport and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005085 : guanyl-nucleotide exchange factor activity and also this GO :0005089 : Rho guanyl-nucleotide exchange factor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005085 : guanyl-nucleotide exchange factor activity, this GO :0005089 : Rho guanyl-nucleotide exchange factor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0046872 : metal ion binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0046872 : metal ion binding, transferring phosphorus-containing groups and molecular function this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0035023 and regulation of Rho protein signal transduction and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0097190 and apoptotic signaling pathway and biological process, kalirin |
| Identity: |
4814 |
| Gene: |
KALRN |
More about : KALRN |
| Long gene name: |
RhoGEF kinase , kalirin |
| Synonyms gene: |
HAPIP |
| Synonyms gene name: |
huntingtin-associated protein interacting protein (duo) |
| Synonyms name: |
serine/threonine kinase with Dbl and pleckstrin homology domains |
| Locus: |
3q21, 1-q21, 2 |
| Discovery year: |
1999-01-13 |
| GenBank acession: |
U94190 |
| Entrez gene record: |
8997 |
| Pubmed identfication: |
9285789 10023074 |
| RefSeq identity: |
NM_003947 |
| Classification: |
Rho guanine nucleotide exchange factors I-set domain containing Fibronectin type III domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000125545 |