| Long name: |
Beta catenin Primary Polyclonal Antibody |
| Also known as: |
Beta catenin PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Beta catenin |
| Specificity: |
This is a highly specific antibody against Beta catenin |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
650-700/781 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Beta catenin |
| Gene ID number: |
1499 |
| Swiss Prot: |
P35222 |
| Tested Applications: |
IF(ICC), IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
APC, AXIN2, Acts as a negative regulator of centrosome cohesion, Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome, CTNNB1 is not ubiquitinated and accumulates in the nucleus, Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML, In the absence of Wnt, In the presence of Wnt ligand, Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization, Involved in the regulation of cell adhesion, forms a complex with AXIN1, leading to activate Wnt responsive genes, where it acts as a coactivator for transcription factors of the TCF/LEF family, Key downstream component of the canonical Wnt signaling pathway |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Beta-catenin, CTNNB1, Catenin beta-1, MRD19, OK/SW-cl, PRO2286, armadillo, 35, CTNNB |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Beta catenin |
| Short name: |
Beta catenin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
b catenin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2514 |
| Gene: |
CTNNB1 |
More about : CTNNB1 |
| Long gene name: |
catenin beta 1 |
| Synonyms gene: |
CTNNB |
| Synonyms gene name: |
88kDa catenin (cadherin-associated protein), beta 1, beta 1 , beta 1 (88kD) catenin (cadherin-associated protein), catenin (cadherin-associated protein) |
| Synonyms: |
beta-catenin armadillo |
| Locus: |
3p22, 1 |
| Discovery year: |
1993-07-13 |
| GenBank acession: |
X87838 |
| Entrez gene record: |
1499 |
| Pubmed identfication: |
7829088 |
| RefSeq identity: |
NM_001098210 |
| Classification: |
NineTeen complex Armadillo repeat containing |
| Havana BLAST/BLAT: |
OTTHUMG00000131393 |
| Locus Specific Databases: |
LRG_1108 |