| Long name: |
RAD50 Primary Polyclonal Antibody |
| Also known as: |
RAD50 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RAD50 |
| Specificity: |
This is a highly specific antibody against RAD50 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
817-872/1312 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RAD50 |
| Gene ID number: |
10111 |
| Swiss Prot: |
Q92878 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
DNA recombination, In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888), PubMed:9590181, PubMed:9651580), PubMed:9705271, RAD50 may be required to bind DNA ends and hold them in close proximity, The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416), The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:11741547, maintenance of telomere integrity and meiosis, which are provided by MRE11A, which plays a central role in double-strand break (DSB) repair, Component of the MRN complex |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
RAD50, hRAD50, DNA repair protein RAD50 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
RAD50 |
| Short name: |
RAD50 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAD50 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9816 |
| Gene: |
RAD50 |
More about : RAD50 |
| Long gene name: |
RAD50 double strand break repair protein |
| Synonyms gene name: |
RAD50 (S, cerevisiae) RAD50 homolog, cerevisiae) homolog RAD50 homolog (S, double strand break repair protein |
| Synonyms: |
hRad50 RAD50-2 |
| Locus: |
5q31, 1 |
| Discovery year: |
1999-07-23 |
| GenBank acession: |
Z75311 |
| Entrez gene record: |
10111 |
| Pubmed identfication: |
8756642 9705271 |
| RefSeq identity: |
NM_005732 |
| Classification: |
BRCA1 C complex MRN complex |
| Havana BLAST/BLAT: |
OTTHUMG00000059613 |