| Long name: |
ALEXA FLUOR 488 Conjugated, Bestrophin 2 Polyclonal Antibody |
| Also known as: |
Anti-Bestrophin 2 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Bestrophin 2 |
| Specificity: |
This is a highly specific antibody against Bestrophin 2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Bestrophin 2 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
1 also known as Best disease, 3 and 4, Bestrophin 2, Bestrophins were originally defined as a family of over 20 related sequences of the C, Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels, It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac), PR65, RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon, Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein, Three more members of the bestrophin family members were cloned and indentified recently, elegans, was confirmed by reciprocal immunoprecipitation, The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Bestrophin 2 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Bestrophin 2 |
| Short name: |
Bestrophin 2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Bestrophin 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
17106 |
| Gene: |
BEST4 |
More about : BEST4 |
| Long gene name: |
bestrophin 4 |
| Synonyms gene: |
VMD2L2 |
| Synonyms gene name: |
vitelliform macular dystrophy 2-like 2 |
| Locus: |
1p34, 1 |
| Discovery year: |
2003-12-03 |
| GenBank acession: |
AF440757 |
| Entrez gene record: |
266675 |
| Pubmed identfication: |
12032738 16702355 |
| RefSeq identity: |
NM_153274 |
| Classification: |
Bestrophins |
| Havana BLAST/BLAT: |
OTTHUMG00000008488 |