| Long name: |
ALEXA FLUOR 647 Conjugated, DNA PKcs POLYCLONAL ANTIBODY |
| Also known as: |
Anti-DNA PKcs PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DNA PKcs |
| Specificity: |
This is a highly specific antibody against DNA PKcs |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DNA PKcs |
| Gene ID Number: |
5591 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Ability to phosphorylate TP53/p53 in the presence of supercoiled DNA is dependent on C1D, Also involved in modulation of transcription, Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA, DHX9, Found at the ends of chromosomes, HSPCA, Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination, May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage, Must be bound to DNA to express its catalytic properties, PARP1, POU2F1, Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, Phosphorylates DCLRE1C, Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C), Recognizes the substrate consensus sequence [ST]-Q, Required to protect and align broken ends of DNA, SRF, The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step, WRN, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, c-Abl/ABL1, c-jun/JUN, c-myc/MYC and RFA2, histone H1, p53/TP53, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion, thereby regulating DNA damage response mechanism, Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
DNA-PK catalytic subunit, DNA-PKcs, DNAPK, DNAPK catalytic subunit, DNPK1, HYRC, HYRC1, PRKDC, PRKDC, PRKDC_HUMAN, Protein Kinase DNA Activated Catalytic Polypeptide, Variant, XRCC 7, XRCC7, p350, p460, DNA-dependent protein kinase catalytic subunit |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the DNA PKcs ANTIBODY, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
DNA PKcs |
| Short name: |
DNA PKcs ANTIBODY |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, Desoxyribonucleic acid PKcs (Antibody to) |