| Long name: |
COMP Primary Polyclonal Antibody |
| Also known as: |
COMP PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
COMP |
| Specificity: |
This is a highly specific antibody against COMP |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
265-300/757 |
| Subcellular location: |
Secreted |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human COMP |
| Gene ID number: |
1311 |
| Swiss Prot: |
P49747 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
BIRC2, BIRC5 and XIAP), Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors, Could play a role in the pathogenesis of osteoarthritis, Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli, Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity), Potent suppressor of apoptosis in both primary chondrocytes and transformed cells, Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
COMP, Cartilage oligomeric matrix protein, EDM1, EPD1, PSACH, THBS5, TSP5, Thrombospondin-5, MED |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
COMP |
| Short name: |
COMP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
cartilage oli this GO meric matrix protein (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, COMP and IDBG-38816 and ENSG00000105664 and 1311, Comp and IDBG-162847 and ENSMUSG00000031849 and 12845, EDM1 and EPD1 and MED and PSACH and THBS5, Extracellular, heparan sulfate proteoglycan binding, this GO :0001501 and skeletal system development and biological process this GO :0002020 and protease binding and molecular function this GO :0003417 and growth plate cartilage development and biological process this GO :0005201 and extracellular matrix structural constituent and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005518 and collagen binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005615 and extracellular space and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007155 and cell adhesion and biological process this GO :0008201 and heparin binding and molecular function this GO :0009887 and organ morphogenesis and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0031012 and extracellular matrix and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043395 and heparan sulfate proteoglycan binding and molecular function this GO :0060173 and limb development and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0002020 : protease binding, this GO :0002020 : protease binding and also this GO :0005201 : extracellular matrix structural constituent and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0005518 : collagen binding and also this GO :0008201 : heparin binding and also this GO :0043395 : heparan sulfate proteoglycan binding, this GO :0005201 : extracellular matrix structural constituent, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0005518 : collagen binding, this GO :0008201 : heparin binding, this GO :0043395 : heparan sulfate proteoglycan binding, 3034 and IDBG-641613 and ENSBTAG00000004630 and 281088, cartilage oli this GO meric matrix protein |
| Identity: |
2227 |
| Gene: |
COMP |
More about : COMP |
| Long gene name: |
cartilage oligomeric matrix protein |
| Synonyms gene: |
PSACH EDM1 EPD1 |
| Synonyms gene name: |
cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) |
| Synonyms: |
MED THBS5 |
| Synonyms name: |
thrombospondin-5 |
| Locus: |
19p13, 11 |
| Discovery year: |
1994-05-24 |
| GenBank acession: |
L32137 |
| Entrez gene record: |
1311 |
| Pubmed identfication: |
7713493 8307576 |
| RefSeq identity: |
NM_000095 |
| Havana BLAST/BLAT: |
OTTHUMG00000169318 |