DC-SIGNR/CD299 Antibody, Cy7 Conjugated

Catalog number:	bs-10064R-Cy7 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	DC-SIGNR/CD299 Antibody, Cy7 Conjugated
Quantity:	0.1ml
Related search:	gene cells antigen human family cdl

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Long name:	Cy7 Conjugated, DC-SIGNR/CD299 Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Cy7
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	DC-SIGNR/CD299
Specificity:	This is a highly specific antibody against DC-SIGNR/CD299
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Subcellular location:	Extracellular
Source:	KLH conjugated synthetic peptide derived from human CD299
Gene ID number:	10332
Tested applications:	IF(IHC-P), FCM
Recommended dilutions:	IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity:	Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	A key molecule, CD209L, CD299 is located on Human chromosome 19p13, CD299 is polymorphic, CD299 is primarily transcribed in the liver and lymph nodes but not in monocyte derived DC, DC SIGN2, Efforts to identify additional type II membrane proteins resulted in the isolation of a related molecule named CD299, Expression of CD299 is restricted to endothelial cells derived from liver sinusoids, Its structure is similar to DC SIGN1 and therefore binds mannose residues in a calcium dependent fashion, This is further supported by a study demonstrating the ability to isolate a large repertoire of CD299 transcripts largely the result of alternative splicing of the 7 coding exons, also known as DC SIGNR (DC SIGN Related), although variable expression in placenta and some monocytic cell lines has also been reported, and L SIGN (liver/lymph nodespecific ICAM3 grabbing nonintegrin), and capillaries, dendritic cell specific ICAM3 grabbing nonintegrin (DC SIGN1), including ICAM3 and HIV 1 gp120, including antigen presentation to T cells and enhancement of transinfection of CD4+ T cells by HIV 1, including both membrane and soluble isoforms of the protein, is involved in regulating interactions between DC and resting T cells, lymph nodes sinuses, since allelic variations of the exon 4 encoded sequence have been isolated, 3 and shares 73-80% amino acid identity with DC SIGN1, Dendritic cells (DC) play a primary role in the immune system as antigen presenting cells
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	743nm/767nm
Synonyms:	HP10347 DC-SIGNR LSIGN DCSIGNR DC-SIGN2
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Conjugated:	These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene target:	DC-SIGNR/CD299 Conjugated
Short name:	Conjugated, DC-SIGNR/CD299 Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Cy7
Alternative name:	cyanine 7 coupled, DC-SIGNR/CD299 (Antibody to)
Alternative technique:	antibodies
Identity:	13523
Gene:	CLEC4M | More about : CLEC4M
Long gene name:	C-type lectin domain family 4 member M
Synonyms gene:	CD209L CD299
Synonyms gene name:	CD299 antigen C-type lectin domain family 4, member M
Locus:	19p13, 2
Discovery year:	2000-09-19
GenBank acession:	AB015629
Entrez gene record:	10332
Pubmed identfication:	10072769
RefSeq identity:	NM_014257
Classification:	CD molecules C-type lectin domain family
Havana BLAST/BLAT:	OTTHUMG00000182432

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