| Long name: |
DC-SIGNR/CD299 Primary Polyclonal Antibody |
| Also known as: |
DC-SIGNR/CD299 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
DC-SIGNR/CD299 |
| Specificity: |
This is a highly specific antibody against DC-SIGNR/CD299 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CD299 |
| Gene ID number: |
10332 |
| Tested Applications: |
FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
A key molecule, CD209L, CD299 is located on Human chromosome 19p13, CD299 is polymorphic, CD299 is primarily transcribed in the liver and lymph nodes but not in monocyte derived DC, DC SIGN2, Efforts to identify additional type II membrane proteins resulted in the isolation of a related molecule named CD299, Expression of CD299 is restricted to endothelial cells derived from liver sinusoids, Its structure is similar to DC SIGN1 and therefore binds mannose residues in a calcium dependent fashion, This is further supported by a study demonstrating the ability to isolate a large repertoire of CD299 transcripts largely the result of alternative splicing of the 7 coding exons, also known as DC SIGNR (DC SIGN Related), although variable expression in placenta and some monocytic cell lines has also been reported, and L SIGN (liver/lymph nodespecific ICAM3 grabbing nonintegrin), and capillaries, dendritic cell specific ICAM3 grabbing nonintegrin (DC SIGN1), including ICAM3 and HIV 1 gp120, including antigen presentation to T cells and enhancement of transinfection of CD4+ T cells by HIV 1, including both membrane and soluble isoforms of the protein, is involved in regulating interactions between DC and resting T cells, lymph nodes sinuses, since allelic variations of the exon 4 encoded sequence have been isolated, 3 and shares 73-80% amino acid identity with DC SIGN1, Dendritic cells (DC) play a primary role in the immune system as antigen presenting cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
C type lectin domain family 4, C-type lectin domain family 4, CD209 antigen like protein 1, CD209 antigen-like, CD209L, CD209L1, CD299 antigen, CLEC4M, DC SIGN related protein, DC SIGN2, DC SIGNR, DC-SIGN related protein, DC-SIGN2, DC-SIGNR, DCSIGN-related protein, DCSIGNR, Dendritic cell-specic ICAM-3-grabbing non-integrin 2, HP10347, L SIGN, LSIGN, Liver/lymph node specic ICAM 3 grabbing nonintegrin, Liver/lymph node-specic ICAM3-grabbing nonintegrin, MGC129964, MGC47866, Mannose binding C-type lectin DC-SIGNR, dendritic cell specic ICAM-3-grabbing nonintegrin 2, member M, member M, C type lectin domain family 4 member M |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DC-SIGNR/CD299 |
| Short name: |
DC-SIGNR/CD299 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DC-SIGNR/CD299 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
13523 |
| Gene: |
CLEC4M |
More about : CLEC4M |
| Long gene name: |
C-type lectin domain family 4 member M |
| Synonyms gene: |
CD209L CD299 |
| Synonyms gene name: |
CD299 antigen C-type lectin domain family 4, member M |
| Synonyms: |
HP10347 DC-SIGNR LSIGN DCSIGNR DC-SIGN2 |
| Locus: |
19p13, 2 |
| Discovery year: |
2000-09-19 |
| GenBank acession: |
AB015629 |
| Entrez gene record: |
10332 |
| Pubmed identfication: |
10072769 |
| RefSeq identity: |
NM_014257 |
| Classification: |
CD molecules C-type lectin domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000182432 |