| Long name: |
NKG2D Primary Polyclonal Antibody |
| Also known as: |
NKG2D PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NKG2D |
| Specificity: |
This is a highly specific antibody against NKG2D |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
130-170/215 |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from rat NKG2D |
| Gene ID number: |
24934 |
| Swiss Prot: |
O70215 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation, Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins, May play a regulatory role in differentiation and survival of NK cells, Participates in NK cell-mediated bone marrow graft rejection, Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, Signaling involves calcium influx, Stimulates perforin-mediated elimination of ligand-expressing tumor cells, culminating in the expression of TNF-alpha, leading to cytotoxic activity, Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CD314, Killer cell lectin-like receptor subfamily K member 1, Klrk1, NK cell receptor D, NK lectin-like receptor, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKLLR, NKR-P2, Nkrp2, NKG2D |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NKG2D |
| Short name: |
NKG2D Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NKG2D (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
18788 |
| Gene: |
KLRK1 |
More about : KLRK1 |
| Long gene name: |
killer cell lectin like receptor K1 |
| Synonyms gene: |
D12S2489E |
| Synonyms gene name: |
DNA segment on chromosome 12 (unique) 2489 expressed sequence killer cell lectin-like receptor subfamily K, member 1 |
| Synonyms: |
NKG2D KLR NKG2-D CD314 |
| Locus: |
12p13, 2 |
| Discovery year: |
2003-12-12 |
| GenBank acession: |
AJ001687 |
| Entrez gene record: |
22914 |
| Pubmed identfication: |
9683661 2007850 |
| RefSeq identity: |
NM_007360 |
| Classification: |
Killer cell lectin like receptors CD molecules C-type lectin domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000168574 |