| Long name: |
HP1(Tyr43) Primary Polyclonal Antibody |
| Also known as: |
HP1(Tyr43) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HP1 Tyr43 |
| Specificity: |
This is a highly specific antibody against HP1 Tyr43 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr43 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from Drosophila Melanogaster HP1 around the phosphorylation site of Tyr43 |
| Gene ID number: |
34119 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Other Species |
| Cross reactive species details: |
Fruit Fly |
| Background of the target antigen: |
Both domains of HP1 are required for binding to native chromatin in vivo, HP1 alpha may interact with lamin B receptor (LBR), HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, It recognizes and binds histone H3 tails methylated at Lys-9, This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane, but they contribute differentially to binding in euchromatin and heterochromatin, leading to epigenetic repression, the chromo shadow domain, HP1 alpha is a component of heterochromatin |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CG8409, HP1, Non-histone chromosomal protein C1A9 antigen, Heterochromatin protein 1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HP1(Tyr43) |
| Short name: |
HP1(Tyr43) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HP1(Tyr43) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1555 |
| Gene: |
CBX5 |
More about : CBX5 |
| Long gene name: |
chromobox 5 |
| Synonyms gene name: |
Drosophila) chromobox homolog 5 , chromobox homolog 5 (Drosophila HP1 alpha) chromobox homolog 5 (HP1 alpha homolog |
| Synonyms: |
HP1Hs-alpha HP1 HP1-ALPHA |
| Synonyms name: |
HP1 alpha homolog (Drosophila) |
| Locus: |
12q13, 13 |
| Discovery year: |
1999-10-12 |
| GenBank acession: |
U26311 |
| Entrez gene record: |
23468 |
| Pubmed identfication: |
8663349 |
| RefSeq identity: |
NM_012117 |
| Classification: |
Chromobox family |
| Havana BLAST/BLAT: |
OTTHUMG00000169700 |