| Long name: |
Cy5, 5 Conjugated, BRCA1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
BRCA1 |
| Specificity: |
This is a highly specific antibody against BRCA1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
970-1020/1863 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic peptide derived from human BRCA1 |
| Gene ID number: |
672 |
| Swiss Prot: |
P38398 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8, Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation, Involved in transcriptional regulation of P21 in response to DNA damage, It is unclear whether it also mediates the formation of other types of polyubiquitin chains, May function as a transcriptional regulator, Regulates centrosomal microtubule nucleation, Required for FANCD2 targeting to sites of DNA damage, Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle, Required for normal cell cycle progression from G2 to mitosis, The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks, ubiquitination and transcriptional regulation to maintain genomic stability, E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
RNF53 BRCC1 PPP1R53 FANCS |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
BRCA1 Conjugated |
| Short name: |
Conjugated, BRCA1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, early onset (Antibody to), 5 coupled, breast cancer 1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BRCA1 and IDBG-52172 and ENSG00000012048 and 672, BRCA1 and IDBG-640630 and ENSBTAG00000022520 and 353120, BRCAI and BRCC1 and BROVCA1 and IRIS and PNCA4 and PPP1R53 and PSCP and RNF53, Brca1 and IDBG-212218 and ENSMUSG00000017146 and 12189, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046600 and negative regulation of centriole replication and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050681 and androgen receptor binding and molecular function this GO :0051571 and positive regulation of histone H3-K4 methylation and biological process this GO :0051572 and negative regulation of histone H3-K4 methylation and biological process this GO :0051573 and negative regulation of histone H3-K9 methylation and biological process this GO :0051574 and positive regulation of histone H3-K9 methylation and biological process this GO :0051865 and protein autoubiquitination and biological process this GO :0070512 and positive regulation of histone H4-K20 methylation and biological process this GO :0070531 and BRCA1-A complex and cellular component this GO :0071158 and positive regulation of cell cycle arrest and biological process this GO :0071681 and cellular response to indole-3-methanol and biological process this GO :0085020 and protein K6-linked ubiquitination and biological process this GO :2000145 and regulation of cell motility and biological process this GO :2000617 and positive regulation of histone H3-K9 acetylation and biological process this GO :2000620 and positive regulation of histone H4-K16 acetylation and biological process, androgen receptor binding, early onset, nuclei, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and biological process this GO :0007059 and chromosome segregation and biological process this GO :0007098 and centrosome cycle and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008274 and gamma-tubulin ring complex and cellular component this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0009048 and dosage compensation by inactivation of X chromosome and biological process this GO :0010212 and response to ionizing radiation and biological process this GO :0015631 and tubulin binding and molecular function this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030521 and androgen receptor signaling pathway and biological process this GO :0030529 and ribonucleoprotein complex and cellular component this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0031436 and BRCA1-BARD1 complex and cellular component this GO :0031572 and G2 DNA damage checkpoint and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031941 and filamentous actin and cellular component this GO :0034446 and substrate adhesion-dependent cell spreading and biological process this GO :0035066 and positive regulation of histone acetylation and biological process this GO :0035067 and negative regulation of histone acetylation and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043009 and chordate embryonic development and biological process this GO :0043234 and protein complex and cellular component this GO :0043627 and response to estrogen and biological process this GO :0044030 and regulation of DNA methylation and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045717 and negative regulation of fatty acid biosynthetic process and biological process this GO :0045739 and positive regulation of DNA repair and biological process this GO :0045892 and negative regulation of transcription, this GO :0000151 and ubiquitin ligase complex and cellular component this GO :0000724 and double-strand break repair via homolo this GO us recombination and biological process this GO :0000793 and condensed chromosome and cellular component this GO :0000794 and condensed nuclear chromosome and cellular component this GO :0001726 and ruffle and cellular component this GO :0003677 and DNA binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0003723 and RNA binding and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005694 and chromosome and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006260 and DNA replication and biological process this GO :0006281 and DNA repair and biological process this GO :0006301 and postreplication repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0006349 and regulation of gene expression by genetic imprinting and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006359 and regulation of transcription from RNA polymerase III promoter and biological process this GO :0006633 and fatty acid biosynthetic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006978 and DNA damage response, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003684 : damaged DNA binding and also this GO :0003713 : transcription coactivator activity and also this GO :0003723 : RNA binding and also this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0015631 : tubulin binding and also this GO :0016874 : ligase activity and also this GO :0019899 : enzyme binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0046872 : metal ion binding and also this GO :0050681 : androgen receptor binding, this GO :0003684 : damaged DNA binding, this GO :0003713 : transcription coactivator activity, this GO :0003723 : RNA binding, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0015631 : tubulin binding, this GO :0016874 : ligase activity, this GO :0019899 : enzyme binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0044212 : transcription regulatory region DNA binding, this GO :0046872 : metal ion binding, this GO :0050681 : androgen receptor binding, breast cancer 1 |
| Identity: |
1100 |
| Gene: |
BRCA1 |
More about : BRCA1 |
| Long gene name: |
BRCA1, DNA repair associated |
| Synonyms gene name: |
breast cancer 1, early onset breast cancer 1 |
| Synonyms name: |
BRCA1/BRCA2-containing complex, complementation group S , regulatory subunit 53 Fanconi anemia, subunit 1 protein phosphatase 1 |
| Locus: |
17q21, 31 |
| Discovery year: |
1991-02-20 |
| GenBank acession: |
U14680 |
| Entrez gene record: |
672 |
| Pubmed identfication: |
1676470 25472942 |
| RefSeq identity: |
NM_007294 |
| Classification: |
Ring finger proteins Protein phosphatase 1 regulatory subunits BRCA1 A complex BRCA1 B complex BRCA1 C complex Fanconi anemia complementation groups |
| Havana BLAST/BLAT: |
OTTHUMG00000157426 |
| Locus Specific Databases: |
Breast Cancer BRCA1 database at LOVD-China LOVD - Leiden Open Variation Database LOVD - Leiden Open Variation Database LRG_292 |