| Long name: |
BK channel Primary Polyclonal Antibody |
| Also known as: |
BK channel PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
BK channel |
| Specificity: |
This is a highly specific antibody against BK channel |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1120-1170/1236 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human BK channel |
| Gene ID number: |
3778 |
| Swiss Prot: |
Q12791 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX), In cochlea cells, In smooth muscles, It is also activated by the concentration of cytosolic Mg(2+), It therefore contributes to repolarization of the membrane potential, Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane, Kinetics of KCNMA1 channels are determined by alternative splicing, Plays a key role in controlling excitability in a number of systems, and innate immunity, caused by ryanodine receptors in the sarcoplasmic reticulum, its activation by high level of Ca(2+), its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map, phosphorylation status and its combination with modulating beta subunits, regulates the membrane potential, regulation of transmitter release, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BK channel, BKCA alpha, BKTM, Calcium-activated potassium channel, Calcium-activated potassium channel subunit alpha-1, K(VCA)alpha, KCNMA, KCNMA1, KCa1, Maxi K channel, MaxiK, SAKCA, SLO-ALPHA, SLO1, Slo homolog, Slowpoke homolog, bA205K10, hSlo, mSLO1, subfamily M subunit alpha-1, 1, 1, SLO |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
BK channel |
| Short name: |
BK channel Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
BK channel (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6287 |
| Gene: |
KCNMB3 |
More about : KCNMB3 |
| Long gene name: |
potassium calcium-activated channel subfamily M regulatory beta subunit 3 |
| Synonyms gene: |
KCNMB2 KCNMBL |
| Synonyms gene name: |
potassium large conductance calcium-activated channel, subfamily M beta member 3 potassium channel subfamily M regulatory beta subunit 3 |
| Synonyms name: |
BK channel beta subunit 3 MaxiK channel beta-subunit 3 big potassium channel beta subunit 3 |
| Locus: |
3q26, 32 |
| Discovery year: |
2000-01-07 |
| GenBank acession: |
AF139471 |
| Entrez gene record: |
27094 |
| Pubmed identfication: |
10585773 |
| Classification: |
Potassium calcium-activated channel subfamily M regulatory beta subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000157337 |