| Long name: |
Spindlin 1 Primary Polyclonal Antibody |
| Also known as: |
Spindlin 1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Spindlin 1 |
| Specificity: |
There is 60% sequence similarity with Spindlin 3, but the sequence is not continuous so the chance of bindin is low, This is a highly specific antibody against Spindlin 1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
10-60/262 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Spindin 1 |
| Gene ID number: |
10927 |
| Swiss Prot: |
Q9Y657 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
In case of cancer, Involved in oocyte meiotic resumption, Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006), May play a role in cell-cycle regulation during the transition from gamete to embryo, Overexpression induces metaphase arrest and chromosomal instability, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551), Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
OCR, Ovarian cancer-related protein, SPIN1, Spindlin-1, Spindlin1, SPIN |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Spindlin 1 |
| Short name: |
Spindlin 1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Spindlin 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11243 |
| Gene: |
SPIN1 |
More about : SPIN1 |
| Long gene name: |
spindlin 1 |
| Synonyms gene: |
SPIN |
| Synonyms gene name: |
spindlin |
| Synonyms: |
TDRD24 |
| Locus: |
9q22, 1 |
| Discovery year: |
1999-08-06 |
| GenBank acession: |
AF317228 |
| Entrez gene record: |
10927 |
| Pubmed identfication: |
16098913 |
| RefSeq identity: |
NM_006717 |
| Classification: |
Tudor domain containing Spindlin family |
| Havana BLAST/BLAT: |
OTTHUMG00000020168 |