| Long name: |
ALEXA FLUOR 488 Conjugated, TGF Beta R1 Polyclonal Antibody |
| Also known as: |
Anti-TGF beta Receptor I PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TGF beta Receptor I |
| Specificity: |
This is a highly specific antibody against TGF beta Receptor I |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
310-360/501 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TGF-beta R1 |
| Gene ID Number: |
7046 |
| Swiss Prot: |
P36897 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4, Also involved in non-canonical, Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation, For instance, SMAD-independent TGF-beta signaling pathways, TGFB2 and TGFB3, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis, TGFBR2, The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes, The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2, This constitutes the canonical SMAD-dependent TGF-beta signaling cascade, Transduces the TGFB1, control of mesenchymal cell proliferation and differentiation, extracellular matrix production, immunosuppression and carcinogenesis, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, wound healing, Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
ACVRLK4, ALK-5, ALK5, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, Serine/threonine-protein kinase receptor R4, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFBR1, TGFR-1, TbetaR-I, Transforming growth factor-beta receptor type I, AAT5 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the TGF Beta R1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
TGF Beta R1 |
| Short name: |
TGF Beta R1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, TGF b R1 (Antibody to) |
| Alternative technique: |
antibodies |