| Long name: |
TGF Beta R1 Primary Polyclonal Antibody |
| Also known as: |
TGF Beta R1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TGF beta Receptor I |
| Specificity: |
This is a highly specific antibody against TGF beta Receptor I |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
310-360/501 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TGF-beta R1 |
| Gene ID number: |
7046 |
| Swiss Prot: |
P36897 |
| Tested Applications: |
FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4, Also involved in non-canonical, Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation, For instance, SMAD-independent TGF-beta signaling pathways, TGFB2 and TGFB3, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis, TGFBR2, The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes, The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2, This constitutes the canonical SMAD-dependent TGF-beta signaling cascade, Transduces the TGFB1, control of mesenchymal cell proliferation and differentiation, extracellular matrix production, immunosuppression and carcinogenesis, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, wound healing, Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ACVRLK4, ALK-5, ALK5, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, Serine/threonine-protein kinase receptor R4, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFBR1, TGFR-1, TbetaR-I, Transforming growth factor-beta receptor type I, AAT5 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TGF Beta R1 |
| Short name: |
TGF Beta R1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TGF b R1 (Antibody to) |
| Alternative technique: |
antibodies |