| Long name: |
SOCS3 Primary Polyclonal Antibody |
| Also known as: |
SOCS3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
SOCS3 |
| Specificity: |
This is a highly specific antibody against SOCS3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
180-215/225 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Socs 3 |
| Gene ID number: |
9021 |
| Swiss Prot: |
O14543 |
| Tested Applications: |
ELISA, FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
ELISA(1:500-1000), FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Binding to JAK2 inhibits its kinase activity, GCSF and leptin receptors, IL12, Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp13, LIF, Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Regulates IL-6 signaling in vivo (By similarity), Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells, SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway, Seems to recognize IL6ST (By similarity), Suppresses fetal liver erythropoiesis, erythropoietin, insulin, SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ATOD4, CIS-3, Cish3, Cytokine-inducible SH2 protein 3, SOCS-3, SOCS3, SSI-3, SSI3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3, CIS3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SOCS3 |
| Short name: |
SOCS3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
suppressor on cytokine signaling 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ATOD4 and CIS3 and Cish3 and SOCS-3 and SSI-3 and SSI3, Cytoplasm, SOCS3 and IDBG-647946 and ENSBTAG00000008441 and 282081, SOCS3 and IDBG-70676 and ENSG00000184557 and 9021, Socs3 and IDBG-214604 and ENSMUSG00000053113 and 12702, protein binding, this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0009968 and negative regulation of signal transduction and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0040008 and regulation of growth and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045595 and regulation of cell differentiation and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060334 and regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060338 and regulation of type I interferon-mediated signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0060670 and branching involved in labyrinthine layer morphogenesis and biological process this GO :0060674 and placenta blood vessel development and biological process this GO :0060707 and trophoblast giant cell differentiation and biological process this GO :0060708 and spongiotrophoblast differentiation and biological process, this GO :0004860 : protein kinase inhibitor activity, this GO :0004860 : protein kinase inhibitor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, suppressor of cytokine signaling 3 |
| Identity: |
19391 |
| Gene: |
SOCS3 |
More about : SOCS3 |
| Long gene name: |
suppressor of cytokine signaling 3 |
| Synonyms: |
SSI-3 CIS3 SOCS-3 Cish3 |
| Locus: |
17q25, 3 |
| Discovery year: |
2002-11-13 |
| GenBank acession: |
AB004904 |
| Entrez gene record: |
9021 |
| Pubmed identfication: |
9266833 9344848 |
| Classification: |
Suppressors of cytokine signaling SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000177513 |
| Locus Specific Databases: |
LRG_619 |