| Long name: |
CDK7 Primary Polyclonal Antibody |
| Also known as: |
CDK7 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CDK7 |
| Specificity: |
This is a highly specific antibody against CDK7 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
10-50/346 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CDK7 |
| Gene ID number: |
1022 |
| Swiss Prot: |
P50613 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
CAK activates the cyclin-associated kinases CDK1, CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), CDK1, CDK2, CDK2, CDK4, CDK4 and CDK6 by threonine phosphorylation, CDK6 and CDK11B/CDK11, CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle, Each different complex controls a specific transition between 2 subsequent phases in the cell cycle, Its expression and activity are constant throughout the cell cycle, POLR2A, Phosphorylates SPT5/SUPT5H, Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA, Required for DNA-bound peptides-mediated transcription and cellular growth inhibition, Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, SF1/NR5A1, Upon DNA damage, allowing its escape from the promoter and elongation of the transcripts, and for activation of CDK2/cyclins during G1-S transition (but not complex formation), but is inactivated in turn by p53/TP53, helping in cell recovery, or to apoptosis, p53/TP53, this feedback loop may lead to an arrest of the cell cycle and of the transcription, thus regulating cell cycle progression, triggers p53/TP53 activation by phosphorylation, Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
39 kDa protein kinase, CAK, CDK-activating kinase 1, CDK7, CDKN7, Cell division protein kinase 7, Cyclin-dependent kinase 7, HCAK, MO15, STK1, Serine/threonine-protein kinase 1, TFIIH basal transcription factor complex kinase subunit, p39 Mo15, p39MO15, CAK1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CDK7 |
| Short name: |
CDK7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CDK7 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1778 |
| Gene: |
CDK7 |
More about : CDK7 |
| Long gene name: |
cyclin dependent kinase 7 |
| Synonyms gene name: |
Xenopus laevis, cdk-activating kinase) , cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) cyclin-dependent kinase 7 (MO15 homolog |
| Synonyms: |
CAK1 CDKN7 MO15 STK1 CAK |
| Locus: |
5q13, 2 |
| Discovery year: |
1994-12-16 |
| Entrez gene record: |
1022 |
| Pubmed identfication: |
8069918 |
| RefSeq identity: |
NM_001799 |
| Classification: |
Cyclin dependent kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000099358 |