| Long name: |
ATF2 Primary Polyclonal Antibody |
| Also known as: |
ATF2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ATF2 |
| Specificity: |
This is a highly specific antibody against ATF2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
415-455/505 |
| Subcellular location: |
Mitochondrion, Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ATF2 |
| Gene ID number: |
1386 |
| Swiss Prot: |
P15336 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type, Dependent on its binding partner, Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro, In concert with CUL3 and RBX1, In the cytoplasm, In the nucleus, The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF), and DNA damage response, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'), cell growth, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, including those involved in anti-apoptosis, inducing mitochondrial leakage and promoting cell death, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, proliferation and death, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM, thereby impairing mitochondrial membrane potential, Transcriptional activator which regulates the transcription of various genes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ATF2, Activating transcription factor 2, CRE-BP1, CREB-2, CREB2, CREBP1, Cyclic AMP-dependent transcription factor ATF-2, Cyclic AMP-responsive element-binding protein 2, Histone acetyltransferase ATF2, TREB7, cAMP response element-binding protein CRE-BP1, cAMP-dependent transcription factor ATF-2, cAMP-responsive element-binding protein 2, HB16 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ATF2 |
| Short name: |
ATF2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ATF2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4232 |
| Gene: |
GDNF |
More about : GDNF |
| Long gene name: |
glial cell derived neurotrophic factor |
| Synonyms: |
ATF1 ATF2 HFB1-GDNF |
| Synonyms name: |
astrocyte-derived trophic factor glial cell line derived neurotrophic factor glial derived neurotrophic factor |
| Locus: |
5p13, 2 |
| Discovery year: |
1995-05-04 |
| Entrez gene record: |
2668 |
| Pubmed identfication: |
8493557 |
| RefSeq identity: |
NM_000514 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000090809 |