| Long name: |
ALEXA FLUOR 488 Conjugated, Dnmt3a Polyclonal Antibody |
| Also known as: |
Anti-Dnmt3a PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Dnmt3a |
| Specificity: |
This is a highly specific antibody against Dnmt3a |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Dnmt3a |
| Gene ID Number: |
1788 |
| Swiss Prot: |
Q9Y6K1 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as a transcriptional corepressor for ZBTB18, Can actively repress transcription through the recruitment of HDAC activity, DNA methylation is coordinated with methylation of histones, It modifies DNA in a non-processive manner and also methylates non-CpG sites, May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1, Plays a role in paternal and maternal imprinting, Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites, Required for methylation of most imprinted loci in germ cells, Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Dnmt3a Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Dnmt3a |
| Short name: |
Dnmt3a Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Dnmt3a (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2978 |
| Gene: |
DNMT3A |
More about : DNMT3A |
| Long gene name: |
DNA methyltransferase 3 alpha |
| Synonyms gene name: |
DNA (cytosine-5-)-methyltransferase 3 alpha |
| Locus: |
2p23, 3 |
| Discovery year: |
1998-07-15 |
| Entrez gene record: |
1788 |
| Pubmed identfication: |
9662389 10433969 |
| RefSeq identity: |
NM_022552 |
| Classification: |
PWWP domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000094777 |
| Locus Specific Databases: |
LRG_459 |