| Long name: |
PPP4C Primary Polyclonal Antibody |
| Also known as: |
PPP4C PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PPP4C |
| Specificity: |
This is a highly specific antibody against PPP4C |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
260-307/307 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PP4C |
| Gene ID number: |
5531 |
| Swiss Prot: |
P60510 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
DNA damage checkpoint signaling, DNA repair, Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity), In response to DNA damage, NF-kappa-B activation and cell migration, The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3, The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-14 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair, activation of c-Jun N-terminal kinase MAPK8, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin, apoptosis, catalyzes RPA2 dephosphorylation, maturation of spliceosomal snRNPs, regulation of histone acetylation, tumor necrosis factor (TNF)-alpha signaling, Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PP-X, PP4C, PPH3, PPP4, PPP4C, PPX, Protein phosphatase X, Serine/threonine-protein phosphatase 4 catalytic subunit, PP4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PPP4C |
| Short name: |
PPP4C Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PPP4C (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9319 |
| Gene: |
PPP4C |
More about : PPP4C |
| Long gene name: |
protein phosphatase 4 catalytic subunit |
| Synonyms gene name: |
catalytic subunit , catalytic subunit protein phosphatase 4, protein phosphatase 4 (formerly X) |
| Synonyms: |
PP4 PPX |
| Synonyms name: |
catalytic subunit , protein phosphatase X |
| Locus: |
16p11, 2 |
| Discovery year: |
1993-01-22 |
| Entrez gene record: |
5531 |
| Pubmed identfication: |
9177794 |
| RefSeq identity: |
NM_002720 |
| Classification: |
Protein phosphatase catalytic subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000132113 |