| Long name: |
Biotin Conjugated, HCV Core protein Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HCV Core protein |
| Specificity: |
This is a highly specific antibody against HCV Core protein |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
1-50/3011 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human HCV-Core |
| Swiss Prot: |
P26664 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Virus |
| Crossreactive species details: |
HCV |
| Antigen background: |
Also regulates many host cellular functions such as signaling pathways and apoptosis, Also represses cell cycle negative regulating factor CDKN1A, Enhances TRAIL mediated apoptosis, Interacts with, May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage, May repress the promoter of p53, May suppress the human FOS and HIV-1 LTR activity, May transactivate human MYC, Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit, Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas, Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation, Rous sarcoma virus LTR, Secreted core protein is able to bind C1QR1 at the T-cell surface, Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, although its effect on death receptors-induced apoptosis remains controvertial, and SV40 promoters, and activates AP-1, and activates STAT3 leading to cellular transformation, and promotes virion budding, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm, resulting in down-regulation of T-lymphocytes proliferation, suggesting that it might play a role in immune-mediated liver cell injury, suggesting that it might play a role in mediated apoptosis, thereby interrupting an important check point of normal cell cycle regulation, Core protein packages viral RNA to form a viral nucleocapsid |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Core protein p21, Core protein p9, HCV core protein, HCV-Core protein, HCVAg, Hepatitis C Virus Core Antigen-C, Hepatitis C Virus core protein, capsid protein, polyprotein precursor, Core protein p19, HCV core antigen |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene: |
2, 3, 4, 5, HCV Core antigens or envelope proteins are used for immunization to obtain diagnostic antibodies, Hepatitis C virus is the cause of , NS genotypes 1, NS4, are small (55&ndash, , , (HCV) NS3, (Hepatocellular carcinoma , 65 , Hepatitis C virus , Liver Cancer , RNA viruses, abbreviated HCC) and , and some cancers such as , enveloped, hepatitis C , in humans, in size), lymphomas , nm , positive-sense , single-stranded |
More about : 2, 3, 4, 5, HCV Core antigens or envelope proteins are used for immunization to obtain diagnostic antibodies, Hepatitis C virus is the cause of , NS genotypes 1, NS4, are small (55&ndash, , , (HCV) NS3, (Hepatocellular carcinoma , 65 , Hepatitis C virus , Liver Cancer , RNA viruses, abbreviated HCC) and , and some cancers such as , enveloped, hepatitis C , in humans, in size), lymphomas , nm , positive-sense , single-stranded |
| Gene target: |
HCV Core protein Conjugated |
| Short name: |
Conjugated, HCV Core protein Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, Hepatitis C virus Core protein (Antibody to) |
| Alternative technique: |
antibodies |