| Long name: |
IRS-4 Primary Polyclonal Antibody |
| Also known as: |
IRS-4 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
IRS-4 |
| Specificity: |
This is a highly specific antibody against IRS-4 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
420-470/1216 |
| Subcellular location: |
Cell membrane |
| Source: |
KLH conjugated synthetic peptide derived from mouse IRS-4 |
| Gene ID number: |
16370 |
| Swiss Prot: |
Q9Z0Y7 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
IGF1R and FGFR1, Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity, Involved in the IGF1R mitogenic signaling pathway, May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2, May be involved in nonreceptor tyrosine kinase signaling in myoblasts, May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis, Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation, Plays a role in growth, Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis, and a complex network of intracellular signaling molecules containing SH2 domains, reproduction and glucose homeostasis, such as insulin receptor, Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Cytotoxic T-lymphocyte-specic protein, Fibrinogen like protein 2, Fibrinogen-like protein 2, Fibroleukin, Prothrombinase, T49, pT49, Fibroleukin |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
IRS-4 |
| Short name: |
IRS-4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
IRS-4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6128 |
| Gene: |
IRS4 |
More about : IRS4 |
| Long gene name: |
insulin receptor substrate 4 |
| Synonyms: |
PY160 IRS-4 |
| Locus: |
Xq22, 3 |
| Discovery year: |
1998-11-24 |
| GenBank acession: |
AF007567 |
| Entrez gene record: |
8471 |
| Pubmed identfication: |
9261155 9553137 |
| RefSeq identity: |
NM_003604 |
| Havana BLAST/BLAT: |
OTTHUMG00000022181 |
| Locus Specific Databases: |
Mental Retardation database |