| Long name: |
ALEXA FLUOR 555 Conjugated, TGF beta R2 Polyclonal Antibody |
| Also known as: |
Anti-TGF beta Receptor II PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TGF beta Receptor II |
| Specificity: |
This is a highly specific antibody against TGF beta Receptor II |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
230-280/567 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TGF beta R2 |
| Gene ID Number: |
7048 |
| Swiss Prot: |
P37173 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4, Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways, TGFB2 and TGFB3, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, TGFBR1, The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes, The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2, This constitutes the canonical SMAD-dependent TGF-beta signaling cascade, Transduces the TGFB1, control of mesenchymal cell proliferation and differentiation, extracellular matrix production, immunosuppression and carcinogenesis, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, wound healing, Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGF-beta receptor type II, TGF-beta receptor type-2, TGF-beta type II receptor, TGFBR2, TGFR-2, TGFbeta-RII, TbetaR-II, Transforming growth factor-beta receptor type II, AAT3 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
TGF beta R2 |
| Short name: |
TGF beta R2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, TGF b R2 (Antibody to) |
| Alternative technique: |
antibodies |