| Long name: |
ALEXA FLUOR 555 Conjugated, Caspase 8 Polyclonal Antibody |
| Also known as: |
Anti-Caspase 8 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Caspase 8 |
| Specificity: |
This is a highly specific antibody against Caspase 8 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
430-482/482 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from mouse Caspase-8 subunit p10 |
| Gene ID Number: |
12370 |
| Swiss Prot: |
O89110 |
| Tested applications: |
IF(ICC), IF(IHC-P) |
| Recommended dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Ac-Asp-Glu-Val-Asp-|-AMC, Binding to the adapter molecule FADD recruits it to either receptor, CAP5 and CAP6) are likely retained in the DISC, CASP4, CASP6, CASP7, CASP9 and CASP1, Cleaves ADPRT, Cleaves and activates CASP3, Hydrolyzes the small-molecule substrate, Likely target for the cowpox virus CRMA death inhibitory protein, May participate in the GZMB apoptotic pathways, Proteolytic fragments of the N-terminal propeptide (termed CAP3, The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases, The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation, Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
MCH5 MACH FLICE Casp-8 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
Caspase 8 |
| Short name: |
Caspase 8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, caspase 8 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1509 |
| Gene: |
CASP8 |
More about : CASP8 |
| Long gene name: |
caspase 8 |
| Synonyms gene name: |
apoptosis-related cysteine peptidase , apoptosis-related cysteine protease caspase 8, caspase 8 |
| Locus: |
2q33, 1 |
| Discovery year: |
1996-11-11 |
| GenBank acession: |
U60520 |
| Entrez gene record: |
841 |
| Pubmed identfication: |
8681376 8681377 |
| RefSeq identity: |
NM_001228 |
| Classification: |
Caspases Death effector domain containing Ripoptosome Death inducing signaling complex |
| Havana BLAST/BLAT: |
OTTHUMG00000132821 |
| Locus Specific Databases: |
CASP8base: Mutation registry for Caspase 8 deficiency LRG_34 |