| Long name: |
Cy7 Conjugated, P53 protein(wt-p53) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy7 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
P53 proteinwt-p53 |
| Specificity: |
This is a highly specific antibody against P53 proteinwt-p53 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
240-290/393 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human P53 |
| Gene ID number: |
7157 |
| Swiss Prot: |
P04637 |
| Tested applications: |
IF(ICC), IF(IHC-P) |
| Recommended dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, Implicated in Notch signaling cross-over, In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1, Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process, Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters, Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1, Isoform 7 inhibits isoform 1-mediated apoptosis, LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation, One of the activated genes is an inhibitor of cyclin-dependent kinases, Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, induces growth arrest or apoptosis depending on the physiological circumstances and cell type, or by repression of Bcl-2 expression, the function is largely independent of transcription, thus stopping cell cycle progression, Acts as a tumor suppressor in many tumor types |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
743nm/767nm |
| Synonyms: |
p53 LFS1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths |
| Gene target: |
P53 protein(wt-p53) Conjugated |
| Short name: |
Conjugated, P53 protein(wt-p53) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy7 |
| Alternative name: |
cyanine 7 coupled, P53 protein(wt-p53) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11998 |
| Gene: |
TP53 |
More about : TP53 |
| Long gene name: |
tumor protein p53 |
| Synonyms name: |
Li-Fraumeni syndrome |
| Locus: |
17p13, 1 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AF307851 |
| Entrez gene record: |
7157 |
| Pubmed identfication: |
6396087 3456488 2047879 |
| RefSeq identity: |
NM_000546 |
| Havana BLAST/BLAT: |
OTTHUMG00000162125 |
| Locus Specific Databases: |
IARC TP53 Mutation Database p53 UMD TP53 mutation database Database of Germline p53 Mutations MUTP53LOAD, Mutant p53 Loss Of Activity Database LRG_321 |