| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, Antibody in 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Chemerin / RARRES2 (N-Terminal) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
Western blot: 1:2000 |
| Notes: |
Titration of the Chemerin antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points |
| Intented use: |
This Chemerin antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q99969 |
| Purity: |
Antigen affinity |
| Description: |
Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, Also acts as a proinflammatory adipokine, Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases, Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells, Exhibits an antimicrobial function in the skin, Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2), Positively regulates adipocyte differentiation, The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production, a process essential for the expansion of white adipose tissue, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues, as well as obesity- related disorders such as type 2 diabetes and cardiovascular disease, but also immature myeloid DCs, causing an increase in secretion of proinflammatory and prodiabetic adipokines, macrophages and natural killer cells, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1), modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, particularly immature plasmacytoid dendritic cells, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, Adipocyte-secreted protein (adipokine) that regulates adipogenesis |
| Immunogen: |
Amino acids 1-35 from the human protein were used as the immunogen for this Chemerin antibody |
| Storage: |
Avoid repeated freeze-thaw cycles, Aliquot the Chemerin antibody and store frozen at -20oC or colder |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Chemerin / RARRES2 |
| Short name: |
Chemerin / RARRES2 Antibody (N-Terminal) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Chemerin / RARRES2 (Antibody to) (N-Terminal) |
| Alternative technique: |
antibodies |
| Identity: |
9868 |
| Gene: |
RARRES2 |
More about : RARRES2 |
| Long gene name: |
retinoic acid receptor responder 2 |
| Synonyms gene name: |
retinoic acid receptor responder (tazarotene induced) 2 |
| Synonyms: |
TIG2 HP10433 |
| Synonyms name: |
chemerin |
| Locus: |
7q36, 1 |
| Discovery year: |
1998-02-03 |
| GenBank acession: |
U77594 |
| Entrez gene record: |
5919 |
| Pubmed identfication: |
9270552 17767914 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000158325 |