| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
JNK/SAPK (pThr183/Tyr185) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Rat |
| Tested applications: |
WB |
| Recommended dilutions: |
Western blot: 1:250-500 |
| Intented use: |
This phospho-JNK/SAPK antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
5601 |
| Uniprot #: |
P45984 |
| Purity: |
Antigen affinity |
| Description: |
BCL10, Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway, In T-cells, In response to oxidative or ribotoxic stresses, In this cascade, In turn, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells, MAPK9/JNK2 phosphorylates a number of transcription factors, Participates also in neurite growth in spiral ganglion neurons, Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock, Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption, Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1, Upon T-cell receptor (TCR) stimulation, When activated, differentiation, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3, is activated by CARMA1, migration, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway, transformation and programmed cell death, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2, Serine/threonine-protein kinase involved in various processes such as cell proliferation |
| Immunogen: |
An amino acid sequence surrounding pThr183 and pTyr185 from the human protein was used as the immunogen for the phospho-JNK/SAPK antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-JNK/SAPK antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
JNK/SAPK (pThr183/Tyr185) |
| Short name: |
JNK/SAPK Antibody (pThr183/Tyr185) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
JNK/SAPK (Antibody to) (pThr183/Tyr185) |
| Alternative technique: |
antibodies |
| Identity: |
6881 |
| Gene: |
MAPK8 |
More about : MAPK8 |
| Long gene name: |
mitogen-activated protein kinase 8 |
| Synonyms gene: |
PRKM8 |
| Synonyms: |
JNK JNK1 SAPK1 |
| Synonyms name: |
JUN N-terminal kinase |
| Locus: |
10q11, 22 |
| Discovery year: |
1998-04-28 |
| GenBank acession: |
L26318 |
| Entrez gene record: |
5599 |
| Pubmed identfication: |
8137421 8654373 |
| Classification: |
Mitogen-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000018172 |