| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Integrin alpha 7 (ITGA7) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:2000-8000 |
| Notes: |
Titration of the Integrin alpha 7 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Integrin alpha 7 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13683 |
| Purity: |
Antigen affinity |
| Description: |
Acts as Schwann cell receptor for laminin-2, Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity), During myogenic differentiation, Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells, and facilitate their localization at laminin-rich sites of secondary fiber formation, but isoform Alpha-7X1B is less active on laminin 1 (In vitro), it may induce changes in the shape and mobility of myoblasts, viability and functional integrity, Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers |
| Immunogen: |
This Integrin alpha 7 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1149-1181 amino acids from the C-terminal region of human ITGA7 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Integrin alpha 7 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Integrin alpha 7 (ITGA7) |
| Short name: |
Integrin alpha 7 Antibody (ITGA7) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
a 7), Integrin a 7 (Antibody to) (integrin |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, ITGA7 and IDBG-38762 and ENSG00000135424 and 3679, ITGA7 and IDBG-636499 and ENSBTAG00000012897 and, Itga7 and IDBG-198684 and ENSMUSG00000025348 and 16404, alpha 7, cell adhesion molecule binding, this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005927 and muscle tendon junction and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007517 and muscle organ development and biological process this GO :0007519 and skeletal muscle tissue development and biological process this GO :0008305 and integrin complex and cellular component this GO :0008360 and regulation of cell shape and biological process this GO :0009986 and cell surface and cellular component this GO :0016477 and cell migration and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0031594 and neuromuscular junction and cellular component this GO :0034677 and integrin alpha7-beta1 complex and cellular component this GO :0042383 and sarcolemma and cellular component this GO :0043236 and laminin binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048514 and blood vessel morphogenesis and biological process this GO :0050839 and cell adhesion molecule binding and molecular function, this GO :0005178 : integrin binding, this GO :0005178 : integrin binding and also this GO :0005515 : protein binding and also this GO :0043236 : laminin binding and also this GO :0046872 : metal ion binding and also this GO :0046982 : protein heterodimerization activity and also this GO :0050839 : cell adhesion molecule binding, this GO :0005515 : protein binding, this GO :0043236 : laminin binding, this GO :0046872 : metal ion binding, this GO :0046982 : protein heterodimerization activity, this GO :0050839 : cell adhesion molecule binding, integrin |
| Identity: |
6143 |
| Gene: |
ITGA7 |
More about : ITGA7 |
| Long gene name: |
integrin subunit alpha 7 |
| Synonyms gene name: |
alpha 7 , integrin |
| Locus: |
12q13, 2 |
| Discovery year: |
1992-02-27 |
| Entrez gene record: |
3679 |
| Pubmed identfication: |
7607681 |
| RefSeq identity: |
NM_002206 |
| Classification: |
Integrin alpha subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000170699 |
| Locus Specific Databases: |
LRG_871 |