| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Hes1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:500 |
| Notes: |
Titration of the Hes1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Hes1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P35428 |
| Purity: |
Antigen affinity |
| Description: |
Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity, May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity), May play a role in a functional FA core complex response to DNA cross- link damage, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity), being required for the stability and nuclear localization of FA core complex proteins, Transcriptional repressor of genes that require a bHLH protein for their transcription |
| Immunogen: |
This mouse Hes1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 205-239 amino acids from the C-terminal region of mouse Hes1 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Hes1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Hes1 |
| Short name: |
Hes1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
(Drosophila) (Antibody to), hairy and enhancer on split 1 |
| Alternative technique: |
antibodies |
| Identity: |
5192 |
| Gene: |
HES1 |
More about : HES1 |
| Long gene name: |
hes family bHLH transcription factor 1 |
| Synonyms gene: |
HRY |
| Synonyms gene name: |
(Drosophila) , hairy homolog (Drosophila) hairy and enhancer of split 1 |
| Synonyms: |
FLJ20408 HES-1 Hes1 bHLHb39 |
| Locus: |
3q29 |
| Discovery year: |
1993-09-21 |
| GenBank acession: |
L19314 |
| Entrez gene record: |
3280 |
| Pubmed identfication: |
8020957 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000155984 |